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Stem cells can thrive in segments of well-vascularized tissue temporarily removed from laboratory animals, say researchers at the Stanford University School of Medicine. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system.
The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure.
“Efforts to use tissue engineering to generate whole organs have largely failed,” said Geoffrey Gurtner,
A spun 3-D scaffold of nanofibers did a better job of producing larger quantities of and a more durable type of the cartilage protein than flat, 2-D sheets of fibers did.
Johns Hopkins tissue engineers have used tiny, artificial fiber scaffolds thousands of times smaller than a human hair to help coax stem cells into developing into cartilage, the shock-absorbing lining of elbows and knees that often wears thin from injury or age.
Reporting online June 4 in the Proceedings of the National Academy of Sciences, investigators say they have produced an important component of cartilage in both laboratory
The study Sun has been working on in Dr. Farshid Guilak’s laboratory has found that engineered cartilage constructed from a particular type of stem cell integrate well with host cartilage, but not necessarily in a uniform way.
Sun was one of about thirty biomedical engineering students who presented at the department’s graduation with distinction reception on April 26. Other students have been working on exciting projects in optic imaging of tumors, synthetic biology, and deep brain stimulation, among other topics.
Sun’s project focused on how induced pluripotent stem cells can be used to study cartilage regeneration and repair.
Pier Paolo Parnigotto with Mariateresa Conconi
After a trachea transplant that was not rejected, performed in Barcelona by Italian surgeon Paolo Macchiarini, soon other organs and biotech tissues will be reconstructed in the lab thanks to a technique developed by the University of Padova. Bones, livers, the esophagus, pancreases, and muscles will be next, in research that will possibly take place in the Veneto. According to Pierpaolo Parnigotto, 61 year old professor of anatomy, who together with Maria Teresa Conconi carried out tissue engineering research for 15 years in the development of biotech organ grafts that
In a first, scientists have grown artificial skin using stem cells derived from the umbilical cord.
Scientists from the Tissue Engineering Research Group at the Department of Histology at the University of Granada demonstrated the ability of Wharton jelly mesenschymal stem cells to turn to oral-mucosa or skin-regeneration epithelia.