Tag Archives: Parkinson’s disease

Precision gene targeting in stem cells corrects disease-causing mutations

Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that have been reprogrammed to an embryonic stem cell-like state).

In one case, scientists employed proteins known as zinc finger nucleases (ZFNs) to change a single base pair in the genome, allowing them either to insert or remove mutations known to cause early-onset Parkinson’s disease (PD). The second method relies on proteins called transcription activator like effector nucleases (TALENs) capable of altering specific genes with similar efficiency and precision as ZFNs.
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RP hospitals now providing stem-cell treatments

The flattening of the world’s economy has spawned a new trend in the local medical-tourism industry: Foreigners are starting to come to the Philippines because of the country’s ever-growing availability of cheap but reliable regenerative or stem-cell treatments.
Dr. Samuel Bernal, consultant on regenerative medicine for the Medical City, said some hospitals in the Philippines are starting to gain vigor in stem-cell treatments. Patients treated last year reached over 100 in number.

“Ours [Philippines] is cheaper compared to other developed and developing nations,” Bernal told the BusinessMirror in a phone interview on Monday after a briefing with the media on “Bioregenerative
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AUSTRALIA – Induced Pluripotent Stem Cell Research Project

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Scientists in Melbourne for the first time have created a human stem cell reserve in Australia using a technique that avoids destroying embryos, which was developed in Japan and the United States.

The team from the Monash medical research institute produced an induced pluripotent stem cell line (IpS) that acts like embryonic stem cells, but are derived from adult skin cells. The method used to reprogram adult stem cells developed last year in Japan and the United States allows for the production of IpSs, which are used to study degenerative diseases like Parkinson’s without having to deal
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Stem cells enhanced by new biomaterial

A new biomaterial that enhances the ability of stem cells to regenerate into nerves and body parts has been developed by Australian and British scientists.

The work was a result of a joint study undertaken by the researchers at the Melbourne-based Monash University and UK-based University of Warwick.

Other biomedical “scaffold” materials, which act as templates for tissue regeneration, already exist but they cannot communicate effectively with the cells they are trying to influence.

The researchers have created a more advanced material that targets specific cells and provides clear signals to these cells to enhance regeneration.

Warning issued against stem cell tourism by experts

Warnings are being issued by experts of the dangers of medical tourism saying that unproven stem cell therapy overseas could leave patients worse off.

Signing up for stem cell therapy is worth the risk for many people who are suffering with conditions like spinal injury, multiple sclerosis, motor neuron or Parkinson’s disease.

A medical journal reported earlier this year that an Israeli teenager developed brain tumors after experimental injections at a Russian clinic.

There are alternate reports also of patients contracting meningitis after treatments in China.

A handbook will be released by the Australian Stem Cell Centre to help patients analyze radial stem
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