When a muscle is damaged, dormant adult stem cells called satellite cells are signaled to “wake up” and contribute to repairing the muscle. University of Missouri researchers recently found how even distant satellite cells could help with the repair, and are now learning how the stem cells travel within the tissue. This knowledge could ultimately help doctors more effectively treat muscle disorders such as muscular dystrophy, in which the muscle is easily damaged and the patient’s satellite cells have lost the ability to repair.
“When your muscles are injured, they send out a ‘mayday’ for satellite cells to come and
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CHICAGO (Reuters) – A new understanding of the genes that make muscle cells may change the way researchers think about stem cell transplants for muscular dystrophy and muscle injuries, U.S. researchers said on Wednesday.
In a surprise finding, they said genes important for forming muscle cells in embryos and newborns are not normally active in adult stem cells.
And researchers hoping to use muscle stem cells in stem-cell transplant therapies should not assume genes that control early muscle development serve the same purpose in repairing adult muscle, Christoph Lepper and colleagues at the Carnegie Institution in Baltimore
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Scientists have made a breakthrough in stem cell research which raises the prospect of regrowing damaged sections of a person’s liver, pancreas or even their brain.
Researchers at the University of NSW have found a way to improve the lifespan and competitiveness of stem cells, overcoming a problem which otherwise saw their regenerative powers fade in about an hour.
Adult stem cells were given a gene to make them resistant to chemotherapy, handing them an “advantage” when used to treat damaged tissue in conjunction with the cancer-fighting treatment.
University of NSW Professor Peter Gunning said as the chemotherapy cleaned out
Douglas A. Melton
Scientists have created stem cells from patients suffering from 10 incurable diseases, from Down syndrome to diabetes and Parkinson’s – immortal cells that might one day be turned into repair material for wasting muscles or damaged brains.
The Harvard University-led team has taken skin and bone marrow cells from diseased patients and re-programmed those cells to behave like cells from days-old embryos.
The feat allows scientists for the first time to watch muscular dystrophy and other diseases unfold in a petri dish, “that is, to watch what goes right or wrong,” said Doug Melton, co-director of the Harvard
Muscle wasting linked to old age might one day be treated using stem cells, claim US scientists.
A University of Colorado team transplanted cells into mice and saw the muscle more than double in size – staying that way even into old age.
They say their work, reported in Science Translational Medicine, may have promise in treating muscle-wasting conditions such as muscular dystrophy.
A UK expert said producing a human treatment might be difficult.
Stem cells are cells found in the body which can divide and become a variety of different types of tissue.
Scientists believe they could potentially help treat a large number