The master regulator of muscle differentiation, MyoD, functions early in myogenesis to help stem cells proliferate in response to muscle injury, according to researchers at Case Western Reserve University.
The study appears online Jan. 4 in the Journal of Cell Biology.
While looking for mechanisms that might be relevant to restoring regenerative potential in older skeletal muscle, HSCI Executive Committee member, Amy Wagers, PhD, and her team, thought about mechanisms that had been studied for a long time evolutionarily as regulating lifespan and longevity. One example of such a mechanism is reduced calorie intake in the absence of malnutrition, also know as calorie restriction, which has been show to extend lifespan in many organisms.
In order to address the question of whether calorie restriction could also affect skeletal muscle regeneration, Wagers and her colleagues placed mice for 12 weeks
Image by kevindooley via Flickr
A biodegradable tissue to repair hearts after a heart attacks or to cure congenital malformations. A tissue that acts like a porous, accordion-like medium onto which cardiac stem cells are ‘implanted’ has been created by scientists from the prestigious Massachusetts Institute of Technology in Boston (MIT). This “bioscaffolding” integrates perfectly with cardiac tissue and creates a biological “band-aid” that is slowly reabsorbed and repairs cardiac muscle.
Compared to similar previous attempts, explained George Engelmayr in “Nature Materials” magazine, the advantage of the “bioscaffolding” is that it faithfully mirrors cardiac tissue structurally and mechanically, and
No Waiting for the Stem Cell Research Debate To Finish
While the debate on stem cell research rages on, Donald Cecil couldn’t afford to wait for research. Donald badly needed treatment for his heart which was damaged by a series of heart attacks. Luckily, he found a stem cell treatment, Vescell in Thailand by using […]
Muscle wasting linked to old age might one day be treated using stem cells, claim US scientists.
A University of Colorado team transplanted cells into mice and saw the muscle more than double in size – staying that way even into old age.
They say their work, reported in Science Translational Medicine, may have promise in treating muscle-wasting conditions such as muscular dystrophy.
A UK expert said producing a human treatment might be difficult.
Stem cells are cells found in the body which can divide and become a variety of different types of tissue.
Scientists believe they could potentially help treat a large number