Tag Archives: Mental disorder

Receives $1.2 Million to Expand Research Capabilities into Autism, Attention Deficit Disorder, Schizophrenia and Major Depression

Rutgers Establishes Stem Cell Repository for the Study of Mental Health Disorders

Rutgers University Cell and DNA Repository (RUCDR) has established a stem cell repository for the National Institute of Mental Health that will better enable researchers to study a variety of mental health disorders, including autism, attention deficit disorder, major depression, and schizophrenia, that affect millions of Americans.

“The biology of mental health disorders has been especially difficult to study because brain tissue from affected individuals is seldom available,” said principal investigator Jay A. Tischfield, Duncan and Nancy Macmillan Professor and director of the Human Genetics Institute. “With the award
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Stem cells to define the origins of Schizophrenia

Scientific consensus holds that most major mental disorders, such as schizophrenia, are genetically rooted diseases of synapses, the connections between neurons in the brain. Now research has demonstrated how a rare mutation in a suspect gene corrupts the on-off switches of dozens of other genes underlying these connections.

The study appears online in the current issue of the journal Nature. Employing a disease-in-dish technology called induced pluripotent stem cells (iPSCs), the team of investigators, including UC Santa Barbara researchers, studied iPSCs from four members of an American family affected by genetically linked schizophrenia and related mental disorders.

Decades ago, researchers traced
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