Andreas Trumpp and his colleagues from the German Cancer Research Center have recently spoken about a “silent reserve” of stem cells, wondering what type of medical impact the discovery made in Heidelberg of “dormant stem cells” could have.
Usually, dormant bone marrow cells activate and multiply only in a crisis or emergency to react to serious cellular loss due to a virus or hemorrhage. When their work is done, they return to a dormant stage. This withdrawal phase keeps them protected from mutations, cellular toxins, and other dangerous substances, since the cells do not divide
Fondazione IRCCS Istituto Nazionale Tumori di Milano
Methods to provide safer stem cell transplants to individuals who are not completely compatible with the donor are being developed. Encouraging results have come from a post-transplant cellular therapy, which strengthens the immune system against viral infections and tumors, developed for the first time at the National Tumor Institute (INT) in Milan. The INT conducted the first phase I-II study in the world, published in ‘Blood’, whose main objective was to assess the use of a low dose radiochemotherapy, followed by low dose post-transplant infusions CD8-depleted donor lymphocytes after
Image via Wikipedia
Promising results from a small study may offer hope for the treatment of multiple sclerosis (MS).
Researchers from the University of California – San Diego report dramatic improvement after treating MS patients with stromal vascular fraction (SVF) stem cells from a patient’s own body fat. They say the SVF therapy can limit the body’s immune system reaction and promote the growth of new myelin – the fatty “insulation” on axons in the brain, which breaks down in patients with MS.
“None of the presently available MS treatments selectively inhibit the immune attack against the nervous system, nor do they
In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
In both mice and a Phase 1 human clinical trial, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for
Bone marrow stem cells self transplant can reduce Multiple Sclerosis (MS) symptoms, and make the disease regress in some cases.
These are the hopeful results from a research on 21 patients diseased by MS, made by the Chicago Northwestern University School of Medicine and published on Lancet Neurology. “Since 3 years from self transplant all the patients watch their conditions better.”
Since these results, doctors decided to make a bigger research involving more MS diseased people and comparing new therapy’s results with olds’ ones.
The experiment is about taking marrow stem cells and then treating them to remove ill lymphocytes which attack