Researchers at the Stanford Institute for Stem Cell Biology and Regenerative Medicine and the Sackler School of Medicine in Israel have shown how the kidneys constantly grow and have surprising ability to regenerate themselves, overturning decades of accepted wisdom that such regeneration didn’t happen. It also opens a path toward new ways of repairing and even growing kidneys.
“These are basic findings that have direct implications for kidney disease and kidney regeneration,” says Yuval Rinkevich, PhD, the lead author of the paper and a postdoctoral scholar at the institute.
The findings were published online May 15 in Cell Reports.
The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest, how stem cells duke it out for space and survival is not as clear. A study on fruit flies published in the October 2 issue of Science by Johns Hopkins researchers describes how stem cells win this battle by literally sticking around.
“Our work exemplifies how one signal coordinately maintains two types of stem cells in a single niche, or microenvironment,” says Erika Matunis,
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CINCINNATI—New research from the University of Cincinnati may help in the recovery of lost vision for patients with corneal scarring.
Winston Whei-Yang Kao, PhD, professor of ophthalmology, along with other researchers in UC’s ophthalmology department found that transplanting human umbilical mesenchymal stem cells into mouse models that lack the protein lumican restored the transparency of cloudy and thin corneas.
Mesenchymal stem cells are “multi-potent” stem cells that can differentiate into a variety of cell types.
These findings are being presented Dec. 8 in San Diego at the 49th Annual Meeting of the American Society of Cell Biology.
“Corneal transplantation is currently
Philip Beachy, PhD, professor of biochemistry and of developmental biology, said they’ve learned that, at an intermediate stage during cancer progression, a single cancer stem cell and its progeny can quickly and completely replace the entire bladder lining.
With their model in place, the researchers then conducted two main experiments in the mice: In the first experiment, they looked to see what would happen in animals exposed to BBN when the sonic-hedgehog-expressing cells were marked with a distinctive fluorescent color. In the second, they used genetic techniques to selectively kill those same cells in animals prior to exposure with BBN.
Image by Gabriela Camerotti via Flickr
Those suffering from a damaged heart can be treated with their own heart cells. According to a recent research, heart stem cells from children with congenital heart disease can rebuild the damaged heart in the laboratory. The findings apparently have great significance in the health zone.
While conducting the research, cells were achieved from patients ranging in age from a few days after birth to 13 years. These patients were previously subjected to routine congenital cardiac surgery. The number of heart stem cells appears greatest in neonates, that reduce with progression in age. Majority of