Scientific consensus holds that most major mental disorders, such as schizophrenia, are genetically rooted diseases of synapses, the connections between neurons in the brain. Now research has demonstrated how a rare mutation in a suspect gene corrupts the on-off switches of dozens of other genes underlying these connections.
The study appears online in the current issue of the journal Nature. Employing a disease-in-dish technology called induced pluripotent stem cells (iPSCs), the team of investigators, including UC Santa Barbara researchers, studied iPSCs from four members of an American family affected by genetically linked schizophrenia and related mental disorders.
Decades ago, researchers traced