Tag Archives: Chemotherapy

Scientists reprogram cancer cells with low doses of epigenetic drugs

Experimenting with cells in culture, researchers at the Johns Hopkins Kimmel Cancer Center have breathed possible new life into two drugs once considered too toxic for human cancer treatment. The drugs, azacitidine (AZA) and decitabine (DAC), are epigenetic-targeted drugs and work to correct cancer-causing alterations that modify DNA.

The researchers said that the drugs also were found to take aim at a small but dangerous subpopulation of self-renewing cells, sometimes referred to as cancer stem cells, which evade most cancer drugs and cause recurrence and spread.

In a report published in the March 20 issue of Cancer Cell, the Johns Hopkins
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3-year-old Hereford boy to begin chemo, stem cell treatment

A 3-year-old South Dakota boy whose brain tumor treatment had been in question because of an insurance dispute is set to begin chemotherapy in Minnesota this week.
Cooper Urbaniak, who suffers from ependymoma, is to be admitted to the University of Minnesota Medical Center Tuesday to begin high-dose chemotherapy and a stem cell transplant.

The family’s insurance provider initially declared the procedure experimental and refused to pay for it. But under an agreement reached last month between Sanford Health Plan and the university, Sanford will pay for the chemotherapy and pay a discounted rate on the stem cell transplant.
Cooper’s father, Joe
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