Tag Archives: Cellular differentiation

From Stem Cells to Lung Cells

Bronchi, bronchial tree, and lungs. (Photo credit: Wikipedia)

How do you grow stem cells into lungs? The question has puzzled scientists for years. First you need the right recipe, and it took BU researchers Darrell Kotton, Tyler Longmire, and Laertis Ikonomou seven years of trial and error and painstaking science to come up with it. “A lot had to happen to make a lung,” says Kotton. “It was a little more complicated than Julia Child’s ‘heat, eat, bon appetit.’”

Kotton is a School of Medicine associate professor of medicine and pathology and codirector of the Center for Regenerative Medicine (CReM),
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What Decides Neural Stem Cell Fate?

A gene called SOX2 acts as a stem cell gatekeeper – only cells expressing it have the potential to become neurons.

Early in embryonic development, the neural crest – a transient group of stem cells – gives rise to parts of the nervous system and several other tissues. But little is known about what determines which cells become neurons and which become other cell types. A team led by Dr. Alexey Terskikh at Sanford-Burnham Medical Research Institute (Sanford-Burnham) recently found that expression of a gene called SOX2 maintains the potential for neural crest stem cells to become neurons in the
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Israeli researchers discover method to neutralize tumor growth in embryonic stem cell therapy

Hebrew University of Jerusalem

Researchers at the Hebrew University of Jerusalem discovered a method to potentially eliminate the tumor-risk factor in utilizing human embryonic stem cells, said the university on Wednesday.
The researchers’ work paves the way for further progress in the promising field of stem cell therapy, said the press release of the university sent to Xinhua.

According to the release, human embryonic stem cells are theoretically capable of differentiation to all cells of the mature human body (and are hence defined as “pluripotent“).
This ability, along with the ability to remain undifferentiated indefinitely in culture, make regenerative medicine using human
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