Tag Archives: California Institute for Regenerative Medicine

Self-Renewing Neural Stem Cells

Abundant precursor cells can become many types of neurons without introducing tumor risk

In a paper published in the April 25 early online edition of the Proceedings of the National Academy of Sciences, researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.

“It’s a big step forward,” said Kang Zhang, MD, PhD,
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4.3 USD MLN for Stem Cell Research in Multiple Sclerosis

A team led by Peter Schultz, Scripps Family Chair Professor and member of the Skaggs Institute for Chemical Biology at The Scripps Research Institute, has been awarded a $4.3 million grant from the California Institute for Regenerative Medicine (CIRM) to research stem-cell-based therapies to treat multiple sclerosis.

Because stem cells can change or differentiate into many different cell types (such as nerve cells, muscle cells, and skin cells), they hold the life-changing medical potential to provide a source of cells to replace those permanently lost by a patient.

The Scripps Research project focuses on restoring the myelin sheath—a protective covering that
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Scientists Identify Critical Process in Stem Cell Development

Scientists at the Gladstone Institutes have discovered that environmental factors critically influence the growth of a type of stem cell — called an iPS cell — that is derived from adult skin cells. This discovery offers newfound understanding of how these cells form, while also advancing science closer to stem cell-based therapies to combat disease.

Researchers in the laboratory of Gladstone Senior Investigator Shinya Yamanaka, MD, PhD, have for the first time shown that protein factors released by other cells affect the “reprogramming” of adult cells into stem cells known as induced pluripotent stem cells, or iPS cells. The scientists
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Stanford creates first PhD program in stem cell science

Stanford University’s Faculty Senate today approved the creation of what officials believe is the first PhD program devoted solely to stem cell science in the nation and, perhaps, the world. The new doctoral program in stem cell biology and regenerative medicine is also the first interdisciplinary doctoral program created by the School of Medicine in recent years.

School officials say the fact that the university is taking the rare step of creating a new doctoral program acknowledges the growing importance of stem cell research in the realm of biomedical science. The senate’s initial approval
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Alzheimer’s disease potential treatment from neural stem cells

Frank LaFerla, left, Mathew Blurton-Jones and colleagues found that neural stem cells could be a potential treatment for advanced Alzheimer's disease

UC Irvine scientists have shown for the first time that neural stem cells can rescue memory in mice with advanced Alzheimer’s disease, raising hopes of a potential treatment for the leading cause of elderly dementia that afflicts 5.3 million people in the U.S.

Mice genetically engineered to have Alzheimer’s performed markedly better on memory tests a month after mouse neural stem cells were injected into their brains. The stem cells secreted a protein that created more neural connections, improving
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