A novel pathway of stem cell activity in human brain that represents potential targets of brain injuries affecting newborns has been identified by researchers at Barrow Neurological Institute at St. Joseph’s Hospital and Medical Center. The recent study, which raises new questions of how the brain evolves, is published in the current issue of Nature, one of the world’s most cited scientific journals.
Nader Sanai, MD, director of Barrow’s Brain Tumor Research Center, led this study, which is the first developmental study of human neural stem cells in a region of the brain called the subventricular zone, the tissue structure
Investigators at the Stanford University School of Medicine have devised a way to monitor neural stem cells after they’ve been transplanted into the brain.
The scientists were able to determine not only whether the stem cells transplanted into living animals survived but whether they matured into nerve cells, integrated into targeted brain circuits and, most important, were firing on cue and igniting activity in downstream nerve circuits.
Research led by Charles Cox at the University of Texas Health Science Center has shown that stem cell therapy given during the critical time window after traumatic brain injury promotes lasting cognitive improvement.
These experiments, which were published in the latest issue of the journal Stem Cells Translational Medicine, provide a pre-clinical model for experiments with larger animals.
After the brain has suffered a traumatic injury, there are few treatment options. Damage to the brain can be severe, and can also cause ongoing neurological impairment. Approximately half of all patients with severe head injuries need surgery to remove or repair ruptured
U.S. researchers have found that a supplemental protein may help restore impaired mobility of people who suffer from a stroke.
Naturally occurring in humans, the protein has proved to work well in restoring motor function in rats after a stroke, according to two new studies by researchers at the University of California, Irvine (UCI).
The researchers hope that the protein will also help humans.
Administered directly to the brain, the protein restores 99 percent of lost movement; if it’s given through the nose, 70 percent of lost movement is regained. Untreated rats improve by only 30 percent.
Report of the Brain Tumor Progress
Recent findings from the Laboratory of Neurobiology at Northeastern, led by biology professor and chair Günther Zupanc, and published online in the scientific journal Neuroscience, demonstrate the mechanism by which new neurons find their ultimate home — research that Zupanc hopes will offer insight into the regenerative potential of the human brain.
In 1989, scientists discovered that two areas of the human brain — the hippocampus and the olfactory bulb — are capable of generating neurons during adulthood. In the last decade, adult stem-cell research has shown that latent stem cells also exist in other regions.
In principle, this information could