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Stem cells can thrive in segments of well-vascularized tissue temporarily removed from laboratory animals, say researchers at the Stanford University School of Medicine. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system.
The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure.
“Efforts to use tissue engineering to generate whole organs have largely failed,” said Geoffrey Gurtner,
A new report brings bioengineered organs a step closer, as scientists from Stanford and New York University Langone Medical Center describe how they were able to use a “scaffolding” material extracted from the groin area of mice on which stem cells from blood, fat, and bone marrow grew. This advance clears two major hurdles to bioengineered replacement organs, namely a matrix on which stem cells can form a 3-dimensional organ and transplant rejection.
Gregg Semenza, M.D., Ph.D.
Blood vessel blockage, a common condition in old age or diabetes, leads to low blood flow and results in low oxygen, which can kill cells and tissues. Such blockages can require amputation resulting in loss of limbs. Now, using mice as their model, researchers at Johns Hopkins have developed therapies that increase blood flow, improve movement and decrease tissue death and the need for amputation. The findings, published online last week in the early edition of the Proceedings of the National Academy of Sciences, hold promise for developing clinical therapies.
“In a young, healthy individual, hypoxia
(…) Three months ago the world’s first cosmetic stem-cell facelift was carried out on Pauline Wills, 55, an office manager from South London, by Dr Aamer Khan from the Harley Street Medical Skin Clinic. It cost £7,500, took nearly six hours under local anaesthetic and Pauline had the added bonus of losing an inch from her tummy.
And because the procedure uses the body’s own stem cells – which makes it a living tissue graft – you grow into your own facelift during the six months afterwards (…)
Stem cells are present throughout the body and one of their functions is
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Scientists have for the first time succeeded in extracting vital stem cells from sections of vein removed for heart bypass surgery. Researchers funded by the British Heart Foundation (BHF) found that these stem cells can stimulate new blood vessels to grow, which could potentially help repair damaged heart muscle after a heart attack.
The research, by Paolo Madeddu, Professor of Experimental Cardiovascluar Medicine and his team in the Bristol Heart Institute (BHI) at the University of Bristol, is published in the leading journal Circulation.