The same genes that are chemically altered during normal cell differentiation, as well as when normal cells become cancer cells, are also changed in stem cells that scientists derive from adult cells, according to new research from Johns Hopkins and Harvard.
Although genetically identical to the mature body cells from which they are derived, induced pluripotent stem cells (iPSCs) are notably special in their ability to self-renew and differentiate into all kinds of cells. And now scientists have detected a remarkable if subtle molecular disparity between the two: They have distinct “epigenetic” signatures; that is, they differ in what gets
Ashok Chakravarti remembers the moment he went blind.
It was on February 18, 2002. He was at work, at a chemical plant, when a pipe carrying sodium hydroxide (caustic soda) started to leak.
“I was fixing the leak when the chemical splashed into my eyes,” he says. The accident damaged the outermost layer of his eyes, the cornea.
Chakravarti is among thousands of Indians who lose their sight in chemical accidents each year.
Today, some of those people can see again, thanks to scientists at the L.V. Prasad Eye Institute, in Hyderabad.
The institute is treating patients with stem cells – not the controversial
Transplanting own stem cells into heart of severe angina patients lessens their pain and improves their ability to walk, a new study has revealed.
The largest national stem cell study for heart disease showed that transplant subjects also experienced fewer deaths than those who didn’t receive stem cells.
In the 12-month Phase II, double-blind trial, subjects’ own purified stem cells, called CD34+ cells, were injected into their hearts in an effort to spur the growth of small blood vessels that make up the microcirculation of the heart muscle (…)
He also said that this study provides the first evidence that a person’s
TaiGen Biotechnology Co., Ltd. announced today that in a phase 1 study in healthy volunteers TG-0054, a chemokine receptor CXCR4 antagonist, was well tolerated and rapidly mobilized stem cells and endothelial progenitor cells from bone marrow into peripheral blood. The number of CD34+ stem cells in circulation after one dose of TG-0054 was equal or higher than reported cell numbers needed for stem cell transplantation in cancer patients. The observed AEs were all mild and transient. A phase 2 study in stem cell transplantation for multiple myeloma, non-Hodgkin lymphoma and Hodgkin disease patients is currently being initiated (…)
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Before going ahead and explaining the possibilities that are on the verge of development based on the regenerative capabilities of a stem cell, let us first understand what a stem cell is actually. Stem cells are the basic group of cells that have the extremely potent capability of regenerating themselves. The process through which they regenerate themselves is known as mitotic cell division and after the division, the previously unspecialized cells turn into specialized cells for specific organs through cellular differentiation.
These cells are not found in unicellular organisms, but are found in varying quantities within all multi