Damaged and aged heart tissue of older heart failure External link patients was rejuvenated by stem cells modified by scientists, according to research presented at the American Heart Association’s Basic Cardiovascular Sciences 2012 Scientific Sessions.
The study is simultaneously published in the Journal of the American College of Cardiology.
The research could one day lead to new treatments for heart failure patients, researchers said.
“Since patients with heart failure are normally elderly, their cardiac stem cells aren’t very healthy,” said Sadia Mohsin, Ph.D., one of the study authors and a post-doctoral research scholar at San Diego State University’s Heart Institute
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A technique that combines nanotechnology with adult stem cells appears to destroy atherosclerotic plaque and rejuvenate the arteries, according to a study reported at the American Heart Association‘s Basic Cardiovascular Sciences 2010 Scientific Sessions – Technological and Conceptual Advances in Cardiovascular Disease.
In the study, nanoparticles (microscopic particles with at least one dimension less than 80 nm) were infused into the heart of pigs along with adult stem cells. After the nanoparticles were heated by laser light, they burned away arterial plaque. However, nanoparticles were less effective at eliminating plaque if not combined with adult stem cells.
A sophisticated imaging system, multi-isotope imaging mass spectrometry (MIMS), demonstrates cell division in the adult mammalian heart. Researchers were surprised to find that new heart muscle cells primarily arose from existing heart muscle cells, rather than stem cells.
Recent research has shown that there are new cells that develop in the heart, but how these cardiac cells are born and how frequently they are generated remains unclear.
In a study from Harvard-affiliated Brigham and Women’s Hospital (BWH), researchers used a novel method to identify the new heart cells and describe their origins.
The research was published today in Nature.
“The question about how
Fat around the waist is commonly seen as a contributing factor to heart attack. Ironically, a company is now testing whether adult stem cells from fat could help prevent long-term damage after a heart attack.
A new medical team is now investigating whether adult stem cells harvested from a person’s own fat, delivered shortly after a heart attack, could prevent some of the cardiac muscle damage that results from blocked arteries.
During a heart attack, blood vessels that deliver blood to the heart muscle are blocked. The lack of oxygen slowly kills the tissue. San Diego-based Cytori Therapeutics has developed
Stem Cell Therapeutics Corp. or the wishes to announce the acceptance and publication of the paper entitled “The Beta-hCG + Erythropoietin in Acute Stroke (BETAS) Study” by the journal “Stroke”, on March 8, 2010.
This paper was authored by Dr. Steven C. Cramer, from the University of California, Irvine, Dr. David Brown at Hoag Memorial Hospital Presbyterian, New Port Beach, Dr. Michael D. Hill of Foothills Hospital at the University of Calgary, and colleagues.
Dr. Allen Davidoff, VP of Product Development, commented as follows:
“The Stroke journal, published by the American Heart Association, is the top journal in the field of stroke