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In the decades-long war on cancer, as of late, researchers had been making little progress in comparison to colleagues treating other conditions, such as cardiac or infectious diseases. “Cancer research has really plateaued out,” William Matsui, an associate professor of oncology at Johns Hopkins University‘s School of Medicine, said at the 2009 World Stem Cell Summit here on Tuesday. But pushing cancer stem cell research “gives us a novel way to study cancer,” said Matsui, who also runs a lab at the university’s Sidney Kimmel Comprehensive Cancer Center.
Cancer and stem cells have had a fraught relationship—not in the least because of early concern that stem cell treatments could in fact spur on cancer through their encouragement of undifferentiated cell growth. But cancer stem cells themselves have gained a more solid toe-hold in the past several years as a potential new target for cancer research.
Cancer stem cells—or CSCs—are presumed to have similar capabilities as healthy stem cells: they can regenerate and differentiate into any cell that makes up the cancer. Such cells are often blamed for relapses in patients who by all other measures appear to have been cured. One of the large problems, however, has been in finding these cells. In some cancers, such as some leukemias, they are suspected to be only one cell in a million.
Cancer stem cells’ persistence has given rise to the so-called dandelion theory of cancer treatment. Researchers and doctors have traditionally worked to obliterate the visible cancerous menace—the tumor, or dandelion weed, as it were. But as anyone with a lawn may be well aware, hacking off the flower does little to stop the root—that is, the stem cell—from regenerating another attack later. So, posits Richard Jones, also at the Sidney Kimmel Comparative Cancer Center, it’s possible that effective drugs may have been abandoned because they were not creating quick, visible responses. Eliminating the root stem cells will cause the tumors to stop growing, but not right away, he explained at the summit.
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