In a world first in children, British and Italian doctors have transplanted a new airway (trachea) into a child and used the child’s own stem cells, in the body, to rebuild it.
The donated trachea was stripped of the donor’s old cells, down to the inert collagen. The child recipient’s bone marrow stem cells were collected, and applied to the graft in situ in the body, to rebuild the cellular component of the trachea. Thus the child’s own cells will be used to make the new airway sealed and effective.
This is the first time that this has been performed
Surgeons in Sweden have replaced the cancerous windpipe of a Maryland man with one made in a laboratory and seeded with the man’s cells.
The windpipe, or trachea, made from minuscule plastic fibers and covered in stem cells taken from the man’s bone marrow, was implanted in November.
The patient, Christopher Lyles, 30, whose tracheal cancer had progressed to the point where it was considered inoperable, arrived home in Baltimore on Wednesday. It was the second procedure of its kind and the first for an American.
“I’m feeling good,” Lyles said in a telephone interview. “I’m just thankful for a second chance
Ciaran Finn-Lynch, who became the first child in the world to undergo a groundbreaking trachea transplant in March this year, is set to return home to Northern Ireland.
Ciaran underwent the transplant, which involved the removal of his own trachea replaced by a donor windpipe, at Great Ormond Street Hospital. Doctors then used Ciaran’s own stem cells from inside his body to build up the donor windpipe and ensure the organ was not rejected.
Four weeks ago, doctors were able to describe the transplant as a success for the first time after proving vascular supply had returned to