University of Minnesota Medical School researchers have developed a new strategy to improve the development of induced pluripotent stem cells (iPS).
Currently, iPS cells are created by introducing four defined genes to an adult cell. The genes reprogram the adult cell into a stem cell, which can differentiate into many different types of the cells in the body. Typically, the four genes introduced are Oct4, Sox2, Klf4 and c-Myc, a combination known as OSKM.
The U of M researchers found that by fusing two proteins – a master stem cell regulator (Oct4) and a fragment of a muscle cell inducer (MyoD)
A 3-year-old South Dakota boy whose brain tumor treatment had been in question because of an insurance dispute is set to begin chemotherapy in Minnesota this week.
Cooper Urbaniak, who suffers from ependymoma, is to be admitted to the University of Minnesota Medical Center Tuesday to begin high-dose chemotherapy and a stem cell transplant.
The family’s insurance provider initially declared the procedure experimental and refused to pay for it. But under an agreement reached last month between Sanford Health Plan and the university, Sanford will pay for the chemotherapy and pay a discounted rate on the stem cell transplant.
Cooper’s father, Joe
From left to right: A normal pig heart, a pig heart after being decellularised, the pig heart prepared for recellularisation. Photos courtesy of the University of Minnesota.
In a medical first, University researchers have created a beating heart in the laboratory. Using detergents, they stripped away the cells from rat hearts until only the nonliving matrix, or “skeleton,” was left; they then repopulated the matrix with fresh heart cells.
If perfected, the technique may be used someday to generate new hearts for patients. In the United States alone, about 5 million people live with heart failure, 550,000 new cases are
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Don’t look for this just yet at your neighborhood clinic, but Minnesota scientists are pushing stem cell therapies into new frontiers — into territory that is so open that doctors and regulators still are shaping practices and policies as they go along.
In one breakthrough, researchers at Mayo Clinic in Rochester obtained stem cells derived from the bone marrow of heart disease patients and guided the cells to help heal, repair and regenerate damaged heart tissue. This is “landmark work,” said an editorial accompanying their research report in Monday’s Journal of the American College of Cardiology.
And last week,
Dean Third used to look forward to weekends spent refereeing local football matches, and outings with his young family. But now even walking to the end of the road can leave him breathless and exhausted.
For the past four years, the father of four has suffered from dilated cardiomyopathy (DCM), a disease of the heart muscle which causes it to enlarge, affecting its ability to pump blood to the arteries.
The condition afflicts 12,000 people in the UK, and for most sufferers the cause is unknown. If uncontrolled it can be fatal, and patients must adhere strictly to a regime of