Tag Archives: University of Minnesota Medical School

Boy whose skin can’t attach is healing

http://mediamill.cla.umn.edu/mediamill/download.php?file=13798.flv#/U_of_M_Sets_Course_For_Cure_of_Fatal_Childhood_Skin_Disease___Academic_Health_Center__University_of_Minnesota_download.php.flv

Physicians at the University of Minnesota and University of Minnesota Children’s Hospital, Fairview have set the path to a cure for a young boy’s fatal genetic skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant. Nate Liao, a 25-month-old from Clarksburg, N.J., underwent the experimental therapy in October 2007.

“We have established a new standard of care for these EB patients, beginning with Nate,” said John Wagner, M.D., the lead University of Minnesota Medical School physician who developed the clinical trial. “Nate’s quality of life is forever changed.”

Because they lack collagen type VII,
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Researchers improve method to create induced pluripotent stem cells

University of Minnesota Medical School researchers have developed a new strategy to improve the development of induced pluripotent stem cells (iPS).

Currently, iPS cells are created by introducing four defined genes to an adult cell. The genes reprogram the adult cell into a stem cell, which can differentiate into many different types of the cells in the body. Typically, the four genes introduced are Oct4, Sox2, Klf4 and c-Myc, a combination known as OSKM.

The U of M researchers found that by fusing two proteins – a master stem cell regulator (Oct4) and a fragment of a muscle cell inducer (MyoD)
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