The metabolic state of glioma stem cells, which give rise to deadly glioblastomas, is significantly different from that of the brain cancer cells to which they give birth, a factor which helps those stem cells avoid treatment and cause recurrence later.
Researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center also found for the first time that these glioma stem cells can change their metabolic state at will, from glycolysis, which uses glucose, to oxidative phosphorylation, which uses oxygen.
The glioma stem cells’ ability to change their metabolic state at will also allow these stem cells
Expanding on previous research providing proof-of-principle that human stem cells can be genetically engineered into HIV-fighting cells, a team of UCLA researchers has now demonstrated that these cells can actually attack HIV-infected cells in a living organism.
The study, published April 12 in the journal PLoS Pathogens, demonstrates for the first time that engineering stem cells to form immune cells that target HIV is effective in suppressing the virus in living tissues in an animal model, said lead investigator Scott G. Kitchen, an assistant professor of medicine in the division of hematology and oncology at the David Geffen School of
Thursday August 4, 2011
Hi everyone. This is Jocelyn Kaiser, a news writer for Science magazine. In today’s chat, we’re talking about last week’s court decision finding that federal funding for human embryonic stem cell research is legal. We’ll discuss what’s next for Sherley v. Sebelius and what it’s like to work in an area of research where policies are always changing. Guest Hank Greely, a law professor at Stanford, is here now and we’re hoping to be joined later by Amander Clark, a stem cell researcher at UCLA. Let’s start with a question for Hank.
Hank, why was this
UCLA stem cell researchers from the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research led by Dr. Amander Clark have developed the first biological resource that maps critical stages of human egg and sperm cell development during fetal life.
The resulting map has important implications for future research of infertility, such as for cancer survivors left unable to create eggs or sperm due to chemotherapy or radiation treatment. Another important result of this research is a better understanding of the cellular origins of testicular cancer, which is believed to begin in males during fetal life.
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Madison, Wisconsin – Soon, some treatments for blinding eye diseases might be developed and tested using retina-like tissues produced from the patient’s own skin, thanks to a series of discoveries reported by a team of University of Wisconsin-Madison stem cell researchers.
The team, led by stem cell scientist and ophthalmologist Dr. David Gamm of the UW School of Medicine and Public Health and former UW scientist Dr. Jason Meyer, used human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells to generate three-dimensional structures that are similar to those present at the earliest stages of retinal