Understanding the genetic underpinnings of the biology of stem cells is crucial for their use in disease research and treatment. Scientists have identified a variety of genetic factors that maintain self renewal properties in embryonic, fetal, and adult stem cells. But whether these cell types are controlled by the same or different molecules is a persisting question.
Recent work from HSCI Principal Faculty Konrad Hochedlinger, PhD, begins to crack that mystery. Sox2 is a gene whose expression is required for maintaining pluripotency in early embryonic cells and regulating tissue development in the fetal stage. But until now, Sox2 expression had
In a new study, researchers have for the first time demonstrated that baboon embryonic stem cells can be programmed to completely restore a severely damaged artery.
These early results show promise for eventually developing stem cell therapies to restore human tissues or organs damaged by age or disease.
“We first cultured the stem cells in petri dishes under special conditions to make them differentiate into cells that are the precursors of blood vessels, and we saw that we could get them to form tubular and branching structures, similar to blood vessels,” John L. VandeBerg, chief scientific officer from Texas Biomedical Research
From a simple blood draw, Krishanu Saha, a researcher in WID’s BIONATES research group and assistant professor of biomedical engineering, could enable doctors to create stem cells to develop drugs personalized to their patients.
As part of his $400,000 National Science Foundation CAREER Award over the next five years, Saha will focus on improving the process to directly evolve DNA sequences and proteins in human stem cells.
Stem cells have the potential to develop into many different cell types, which makes them ideal for a variety of medical research projects.
The evolution of synthetic DNA sequences in human stem cells could catalyze
Life Stem Genetics announced today a strategic collaborative agreement with American CryoStem Corporation.
CRYO is a leading developer, marketer and global licensor of patented adipose tissue-based cellular technologies for the Regenerative and Personalized Medicine industries.
Adipose tissue is an anatomical term for loose connective tissue (fat) composed of adipocytes (cells). It is used in LIFS stem cell procedures and currently is extracted via liposuction each time a patient has a treatment.
Revolutionary as they may be, stem cells cannot escape the need for food. And until now, that food has represented a costly part of developing stem cells.
But that is about to change. The East Greenbush-based Neural Stem Cell Institute has developed a new substance that will substantially lower development costs.
“Stem cells are unstable,” as Christopher Fasano, the Institute’s director of research and development, says. He explains that they need a constant supply of food and a substance called a “growth factor,” or they start developing into different types of body tissues on their own, and cease being useful to