Tag Archives: Tissue (biology)

New kidney tissues from stem cells

Researchers in Japan said on Wednesday they have succeeded in growing human kidney tissue from stem cells for the first time in a potential breakthrough for millions with damaged organs who are dependent on dialysis.

Kidneys have a complex structure that is not easily repaired once damaged, but the latest findings put scientists on the road to helping a diseased or distressed organ fix itself.

Kenji Osafune of Kyoto University said his team had managed to take stem cells — the “blank slates” capable of being programmed to become any kind of cell in the body — and nudge them specifically
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Human Lung Stem Cell Discovered

For the first time, researchers at Brigham and Women’s Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels.  This research is published in the May 12, 2011 issue of the New England Journal of Medicine.

“This research describes, for the first time, a true human lung stem cell.  The discovery of this stem cell has the potential to offer those who suffer from chronic lung diseases a totally novel treatment option by regenerating or repairing damaged areas of the
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Scientists make eye’s retina from stem cells

“Generation of a synthetic retina from embryonic stem cells is a landmark discovery that will help enormously our understanding of blinding eye disease” (Professor James Bainbridge of Moorfields Eye Hospital NHS Foundation Trust)

A part of the eye that is essential for vision has been created in the laboratory from animal stem cells, offering hope to the blind and partially sighted.

One day it might be possible to make an eye in a dish, Nature journal reports.

The Japanese team used mouse stem cells – immature cells that have the ability to turn into many types of body tissue (…)
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A New Role for Old Sox

Understanding the genetic underpinnings of the biology of stem cells is crucial for their use in disease research and treatment. Scientists have identified a variety of genetic factors that maintain self renewal properties in embryonic, fetal, and adult stem cells. But whether these cell types are controlled by the same or different molecules is a persisting question.

Recent work from HSCI Principal Faculty Konrad Hochedlinger, PhD, begins to crack that mystery. Sox2 is a gene whose expression is required for maintaining pluripotency in early embryonic cells and regulating tissue development in the fetal stage. But until now, Sox2 expression had
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Stem cells may help heal damaged arteries

In a new study, researchers have for the first time demonstrated that baboon embryonic stem cells can be programmed to completely restore a severely damaged artery.

These early results show promise for eventually developing stem cell therapies to restore human tissues or organs damaged by age or disease.

“We first cultured the stem cells in petri dishes under special conditions to make them differentiate into cells that are the precursors of blood vessels, and we saw that we could get them to form tubular and branching structures, similar to blood vessels,” John L. VandeBerg, chief scientific officer from Texas Biomedical Research
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