Stem Cell Corporation Scientists Create New Protein-Based Stem Cell Technology

Posted on 29 April 2013 by Stem Man

International Stem Cell Corporation announced that scientists in its wholly-owned subsidiary, Lifeline Cell Technology (LCT), have developed a technology to modify human stem cells by using engineered proteins, called “transducible transcription factors” or “TTFs.” TTFs are designed to pass into stem cells and direct the stem cells to change into specific cell types that can be both therapeutically-useful and can be used as revenue-generating research products.

In contrast to more traditional cell therapy methods this technology does not require the use of viruses or chemicals, and has the potential to produce safe therapeutic cells from stem cells. In addition, the TTF proteins are naturally eliminated by the cells when no longer required, a characteristic that further improves safety.

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SANUWAVE’S PACE Shows Promise In Stimulating Autogenous Sources Of Progenitor/STEM Cells For Harvest And Re-Transplantation In Bone Tissue Engineering

Posted on 15 April 2013 by Stem Man

SANUWAVE Inc., an emerging medical technology company focused on the development and commercialization of non-invasive, biological response activating devices in the regenerative medicine area, reported that scientific findings titled “Extracorporeal Shock Wave Stimulation of Osteoprogenitor Cells” were presented at the 2009 International Bone-Tissue-Engineering Congress (“Bone-Tec”) in Hannover, Germany, which was held October 9-11, 2009.

Dr. Myron Spector, PhD, Professor of Orthopaedic Surgery (Biomaterials) at Harvard Medical School, Director of Orthopaedic Research at Brigham and Women’s Hospital and Director of Tissue Engineering at VA Boston Healthcare System, was an invited guest speaker at the Conference. The Bone–Tec Congress featured an international scientific forum to discuss progresses in modern bone tissue regeneration and extended a worldwide network to exchange findings on the latest developments.

Dr. Spector’s team employed SANUWAVE’s Pulsed Acoustic Cellular Expression (PACE™) technology in preclinical research to create autogenous sources of stem cells for bone tissue engineering. Results support the proposition that PACE™ could be employed as a non-invasive technique to cause proliferation and thickening of the cambium layer of the femur’s periosteum for the subsequent intraoperative harvesting of progenitor stem cells days later for bone or cartilage regeneration.

PACE™ stimulated a dramatic proliferation and thickening (up to 10 fold) of osteoprogenitor stem cells, precursors to bone and cartilage cells, in the cambium layer of the periosteum in the femur of the adult rats within 4 days. Neovascularization and new bone formation within the thickened periosteum were also evident after 4 days.

Dr. Spector said, “This research has shown great potential. Through more study, this technology could further advance tissue engineering autologous transplant techniques towards clinical applications such as bone reconstruction and cartilage defect repair.” (…)

from http://www.sanuwave.com

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New Strategy Advances Stem Cell Culture Techniques

Posted on 12 April 2013 by Stem Man

Stem cells – unspecialized cells that have the potential to develop into different types of cells – play an important role in medical research. In the embryotic stage of an organism’s growth, stem cells develop into specialized heart, lung, and skin cells, among others; in adults, they can act as repairmen, replacing cells that have been damaged by injury, disease, or simply by age.

Given their enormous potential in future treatments against disease, the study and growth of stem cells in the lab is widespread and critical. But growing the cells in culture offers numerous challenges, including the constant need to replenish a culture medium to support the desired cell growth.

Tarek Fahmy, Associate Professor of Biomedical Engineering & Chemical & Environmental Engineering, and colleagues have developed a nanoparticle-based system to deliver growth factors to stem cells in culture. These growth factors, which directly affect the growth of stem cells and their differentiation into specific cell types, are ordinarily supplied in a medium that is exchanged every day. Using the researchers’ new approach, this would no longer be necessary.

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International Stem Cell Corporation, Through Its Subsidiary Lifeline Cell Technology, Announces the Launch and Sale of New Products into the Human Cell Research Market

Posted on 19 March 2013 by Stem Man

International Stem Cell Corporation, announces that it has launched fifteen new human cell culture products into the commercial research markets over the last twelve months through its wholly-owned subsidiary, Lifeline Cell Technology, (Walkersville, MD), leading to a 12-month average month-to-month revenue growth of 50%. ISCO, the parent company, is the first company to create human “parthenogenetic” stem cells from unfertilized eggs. Parthenogenetic stem cells not only solve ethical problems, but also promise to minimize immune-rejection by providing cells that can be immune-matched to large segments of the population.

These products represent milestone achievements in ISCO’s strategy of generating revenue from the sale of research products, while building infrastructure from that effort to expand the manufacturing and quality control capacities ISCO needs to commercialize the therapeutic applications of human parthenogenetic stem cells.

One of its newest and most promising products consist of “xeno-free” human cells and culture reagents that allow researchers to study embryonic stem cells without contamination from animal (non-human) components. These products meet the needs for stem cell research to be done using “human-only” systems. Other products include Lifeline’s living human cells and reagents for research and drug development into cardiovascular, kidney, lung, nerve, eye and skin disease. Lifeline is continuing to develop unique reagents and media for the growing field of stem cell research. The “Lifeline” brand of products consist of human cells and the culture reagents and growth factors needed to grow the cells.

According to Jeffrey Janus, CEO of Lifeline, “We are proud of the quality of our new products, as reflected in the sales growth they are exhibiting in the human cell research markets. We look forward to launching more new products into the growing markets for stem cell research and drug development. These products will contribute to the success of ISCO, not only by supporting ISCO’s therapeutic research, but also through the development of critical manufacturing and quality control systems necessary for ISCO to produce therapeutic human cells in the future.”

Lifeline’s products can be found at www.lifelinecelltech.com
For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO’s video, a fact sheet on the company, investor presentations, and more.

from http://www.internationalstemcell.com

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SpineSmith to Present at the 5th Annual Stem Cell Summit

Posted on 14 June 2012 by Stem Man

: Image via Wikipedia

Dr. Robert Johnson, MD, of Neurosurgical Associates of San Antonio, is presenting at the 5th Annual Stem Cell Summit in New York on February 16, 2010. Dr. Johnson will be presenting his most recent data proving the efficacy of point of care adult stem cell therapies in spine surgery. Point of care technology utilizes the patient’s own cells derived from bone marrow to inhibit bone growth in spinal fusion procedures. Dr. Johnson believes promoting cell therapy utilizing the patient’s own cells will change the future landscape of medicine.

“The use of autologous stem cells is revolutionizing medical care in both the prevention and treatment of spinal disorders,” said Johnson.

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