Tag Archive for 'Stem cell'Page 5 of 92

DaVinci: Stem cell treatment helped spinal cord patients

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Following up on eight acute and chronic spinal cord injury patients who were injected with bone marrow stem cells two years ago, researchers say that the therapy proved safe and effective in improving their quality of life.

DaVinci Biosciences undertook the study in Ecuador and have now issued a follow-up report claiming that MRIs have revealed “noticeable morphological changes within the spinal cord after administration of autologous bone marrow derived stem cells.” There was no tumor formation, increased pain or deterioration of function following administration of the stem cell treatment.

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USA – MS: Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

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Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible progress, measured in terms of the scale of their disability.”

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Scientists measure communication between stem cell-derived motor neurons, muscle cells

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In an effort to identify the underlying causes of neurological disorders that impair motor functions such as walking and breathing, UCLA researchers have developed a novel system to measure communication between stem cell–derived motor neurons and muscle cells in a Petri dish.
The study provides an important proof of principle that functional motor circuits can be created outside the body using these neurons and cells and that the level of communication, or synaptic activity, between them can be accurately measured by stimulating the motor neurons with an electrode and then tracking the transfer of electrical activity into the muscle cells to which the neurons are connected.
When motor neurons are stimulated, they release neurotransmitters that depolarize the membranes of muscle cells. This allows calcium and other ions to enter the cells, causing them to contract. By measuring the strength of this activity, one can get a good estimation of the overall health of motor neurons.
That estimation could shed light on a variety of neurodegenerative diseases, such as spinal muscular atrophy and amyotrophic lateral sclerosis (Lou Gehrig’s disease), in which communication between motor neurons and muscle cells is thought to unravel, said the study’s senior author, Bennett G. Novitch, an assistant professor of neurobiology and a scientist with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

UT Houston enrolls first patient in stem cell study for stroke

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Roland Bud Henrich, 61, was the first stroke patient to be enrolled in a Phase I trial using his own stem cells.

Roland "Bud" Henrich, 61, was the first stroke patient to be enrolled in a Phase I trial using his own stem cells.

For the first time in the United States, a stroke patient has been intravenously injected with his own bone marrow stem cells as part of a research trial at The University of Texas Medical School at Houston.
Sean Savitz, M.D., assistant professor of neurology at The University of Texas Medical School at Houston, leads a first-of-its-kind bone marrow stem cell therapy study for stroke patients.

Roland “Bud” Henrich, 61, was transferred to Memorial Hermann – Texas Medical Center on March 25 after suffering a stroke while working on his farm in Liberty. He arrived too late to receive tissue plasminogen activator (tPA), the only treatment for ischemic strokes. He became the first patient in the trial.

The Phase I safety trial, funded with a pilot grant from The National Institutes of Health and support from the Notsew Orm Sands Foundation, will enroll nine more patients who have suffered a stroke and can be treated with the stem cell procedure within 24 to 72 hours of initial symptoms.

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ITALY – Ferrari Donates 320 Thousand Euros to Stem Cell Research

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A substantial donation made by Ferrari of 320.000 euros will aid in the development of activities ongoing at the Woman and Infant’s Research Laboratory at the University Hospital in Modena. The presentation of the laboratory, located on the 7th floor of the hospital, and recently restructured, was presented yesterday to Ferrari President Luca di Montezemolo, regional Health councilor Giovanni Bissoni, Vice-Chancellor of the University of Modena and Reggio Emilia Aldo Tomasi, Mayor Pighi, President of the Province Sabattini, and the heads of the hospital.

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Repair cartilage using stem cells

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The study Sun has been working on in Dr. Farshid Guilak’s laboratory has found that engineered cartilage constructed from a particular type of stem cell integrate well with host cartilage, but not necessarily in a uniform way.

Sun was one of about thirty biomedical engineering students who presented at the department’s graduation with distinction reception on April 26. Other students have been working on exciting projects in optic imaging of tumors, synthetic biology, and deep brain stimulation, among other topics.

Sun’s project focused on how induced pluripotent stem cells can be used to study cartilage regeneration and repair.

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