Tag Archives: Shinya Yamanaka

Researchers cure mice with damaged spines using human iPS cells

A team at Keio University has used stem cells to cure mice whose hind legs were paralyzed due to spinal cord damage, the researchers reported Wednesday at a Tokyo symposium.
The team transplanted neural stem cells grown from human iPS cells.

Team leader Hideyuki Okano, a physiology professor at Keio, said it is the first time in the world in which the curative effects of “induced pluripotent stem cells,” or iPS cells, have been confirmed.
Currently, there is no effective treatment for spinal nerve damage and treatment using iPS cells gives hope of a cure.

“It is valuable that treatment using human iPS
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StemCells can avoid rejection from the immune system

Last year, Japanese researchers announced that the first human patient would be treated with induced pluripotent stem cells in an attempt to reverse a degenerative eye condition called macular degeneration that leads to vision loss.

Now, a team of scientists headed by biologists at UC San Diego has discovered how induced pluripotent stem (iPS) cells, which are derived from an individual’s own cells, could be programmed to avoid rejection from the immune system.

Their findings, published online ahead of print in the journal Cell Stem Cell, show that iPS cells can differentiate or change into various types of functional cells with
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Scientists hail stem cell breakthrough

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SCIENTISTS HAVE taken another important step towards producing replacement tissues for the body using stem cells. A group in Germany has developed a simpler way to produce these cells using just one special factor instead of the usual four.

The work helps build knowledge of how to produce the most powerful or “pluripotent” stem cells but new treatments using them are still some distance into the future, according to stem cell specialist Dr Stephen Sullivan.

Prof Hans Schöler led the work at the Max Planck Institute for Molecular Biomedicine and details are published this morning online by the journal
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GERMANY – Stem Cells, One Factor Can Almost Transform Adult Stem Cells into Embryonic Stem Cells

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One factor, not four like a majority of biologists throughout the world have said up until now, is sufficient to convert an adult stem cell into a cell that is similar to an embryonic stem cell. A recipe that is much more simple than what the scientific community has believed has been discovered by Hans Schöler and his colleagues, who include Italians ,Vittorio Sebastiano and Luca Gentile, from the Max Planck Institute for Molecular Biomedicine in Germany. The study, published in February’s edition of Cell, shows for the first time that nerve stem cells taken from
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Wide-ranging applications for pluripotent stem cells

While applications of induced pluripotent stem cells in stem cell therapy may be limited to a few diseases, its applications in drug discovery are wide-ranging, and many more diseases can be targeted, Shinya Yamanaka, Director, Centre for iPS Cell Research and Application, Japan, has said.

The Japanese scientist, whose breakthrough was the creation of embryonic-like stem cells from adult skin cells, believes that the best chance for stem cell therapy lies in offering hope to those suffering from a few conditions, among them, macular disease, Type 1 Diabetes, and spinal cord injuries.

On the other hand, there were multiple possibilities with
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