Tag Archives: Science Translational Medicine

Synthetic Cardiac Stem Cells Offer Less Risks

Stem cell therapy represents a promising strategy in regenerative medicine. However, cells need to be carefully preserved and processed before usage. In addition, cell transplantation carries immunogenicity and/or tumourigenicity risks.

Mounting lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion (of regenerative factors) and membrane-based cell–cell interaction with the injured cells. Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recapitulates stem cell functions in tissue repair.

CMMPs carry similar secreted proteins and membranes as genuine cardiac stem cells do. In a mouse model of myocardial infarction, injection of CMMPs leads to the preservation of viable
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leukemias arise from changes that accumulate in blood stem cells

Imagine that a police bomb squad comes upon a diabolically designed bomb controlled by a tangled mass of different wires, lights and switches, some of which have a real function while others are decoys. The police don’t know how to begin defusing the bomb because they don’t know which parts are important. Then imagine the police discover the bomb-making factory and are able to see hundreds of these bombs at various stages of construction. With this information, they can reconstruct how the bomb was put together, and therefore how to disarm it.

For a team of researchers at
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