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Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. However, the low efficiency and slow kinetics of the reprogramming process have hampered progress with this technology. Here we report that a natural compound, vitamin C (Vc), enhances iPSC generation from both mouse and human somatic cells. Vc acts at least in part by alleviating cell senescence, a recently identified roadblock for reprogramming.
In addition, Vc accelerates gene expression changes and promotes the transition of pre-iPSC colonies to a fully reprogrammed state. Our results therefore highlight a straightforward method for improving the speed and
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The great promise of induced pluripotent stem cells is that the all-purpose cells seem capable of performing all the same tricks as embryonic stem cells, but without the controversy.
However, a new study published this week (Feb. 15) in the Proceedings of the National Academy of Sciences comparing the ability of induced cells and embryonic cells to morph into the cells of the brain has found that induced cells — even those free of the genetic factors used to program their all-purpose qualities — differentiate less efficiently and faithfully than their embryonic counterparts.
The finding that induced cells are
With veterinarians across the country training to use stem cells for tendon and ligament repair, a professor at the University of California, Davis (UC Davis) wants to take the technology a step further by applying them to chronic, cell-based diseases.
Richard Vulliet, DVM, is very early into the work. But he is optimistic about the evidence as it exists, of course, and he may have had a success.
Vulliet has treated four dogs with degenerative myelopathy with their own stem cells, which he prefers to call mesenchymal stem cells or pluripotent marrow stromal cells. The terminology has evolved and those names
A new method to reprogram adult cells making them similar to stem cells has been discovered. The key protein in the discovery is Wnt, already known to scientists for its involvement in numerous phases of development in vertebrates and invertebrates. The study, conducted by the Telethon Institute of Genetics and Medicine (TIGEM) in Naples by Maria Pia Cosma, was published in the online version of Cell Stem Cell magazine. The study involved various types of adult cells including fibroblasts, thymus cells, and neural precursor cells, which were fused with embryonic stem cells in the presence of the
The Australian Stem Cell Centre (ASCC) through StemCore, its national facility for the provision of stem cells and advice, continues to build a world class Australian stem cell research community. For the first time in Australia, young researchers will be trained in the techniques of growing and using human induced pluripotent stem (iPS) cells in research.
iPS cells, discovered in 2006 when Japanese scientists reprogrammed ordinary skin cells into versatile stem cells, have made a significant impact on Australian research and are recognised as one of the most important developments in stem cell research in recent times. By