Tag Archives: Pluripotency

ITALY – New Method Found to Program Adult Stem Cells

A new method to reprogram adult cells making them similar to stem cells has been discovered. The key protein in the discovery is Wnt, already known to scientists for its involvement in numerous phases of development in vertebrates and invertebrates. The study, conducted by the Telethon Institute of Genetics and Medicine (TIGEM) in Naples by Maria Pia Cosma, was published in the online version of Cell Stem Cell magazine. The study involved various types of adult cells including fibroblasts, thymus cells, and neural precursor cells, which were fused with embryonic stem cells in the presence of the
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Training Australian Scientists in Latest Stem Cell Discoveries

The Australian Stem Cell Centre (ASCC) through StemCore, its national facility for the provision of stem cells and advice, continues to build a world class Australian stem cell research community. For the first time in Australia, young researchers will be trained in the techniques of growing and using human induced pluripotent stem (iPS) cells in research.

iPS cells, discovered in 2006 when Japanese scientists reprogrammed ordinary skin cells into versatile stem cells, have made a significant impact on Australian research and are recognised as one of the most important developments in stem cell research in recent times. By
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“Liposuction leftovers” easily converted to induced pluripotent stem cells

Image by shuuki via Flickr

Globs of human fat removed during liposuction conceal versatile cells that are more quickly and easily coaxed to become induced pluripotent stem cells, or iPS cells, than are the skin cells most often used by researchers, according to a new study from Stanford’s School of Medicine. The findings were published online Monday in the Proceedings of the National Academy of Sciences.

“We’ve identified a great natural resource,” said Stanford surgery professor and co-author of the research, Michael Longaker, who has called the readily available liposuction leftovers “liquid gold.” Reprogramming adult cells to function like embryonic stem
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Stem Cells Used to Create New Jaw Bone

Like Samson, researchers in the field of stem cells have used the jawbone to make a point. Dr. Gordana Vunjak-Novakovic and her team at Columbia University have manipulated adult stem cells to grow one of the most difficult sections of bone to replace, the temporomandibular joint. This jawbone was created by allowing pluripotent cells harvested from marrow to grow in a scaffold that was fashioned to mimic the TMJ’s shape.

It is the first accurate and anatomically sized bone created by stem cells in a lab. Dr. Vunjak-Novakovic hopes that this new creation will serve as a proof of concept
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Scientists Reveal How Induced Pluripotent Stem Cells Differ From Embryonic Stem Cells and Tissue of Derivation

The same genes that are chemically altered during normal cell differentiation, as well as when normal cells become cancer cells, are also changed in stem cells that scientists derive from adult cells, according to new research from Johns Hopkins and Harvard.

Although genetically identical to the mature body cells from which they are derived, induced pluripotent stem cells (iPSCs) are notably special in their ability to self-renew and differentiate into all kinds of cells. And now scientists have detected a remarkable if subtle molecular disparity between the two: They have distinct “epigenetic” signatures; that is, they differ in what gets
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