Tag Archives: Piwi-interacting RNA

The Role of Hiwi in Stem Cell Maintenance and Sarcomagenesis

Sarcomas are cancers of connective tissues, such as bone, adipose and cartilage, and are thought to arise from the aberrant development of the mesenchyme. As such, mesenchymal stem cells are thought to be the cell of origin for sarcomas. Genetic or epigenetic lesions at particular points during the differentiation of a mesenchymal stem cell into its terminal mesenchymal cell type are able to give rise to specific subtypes of sarcomas.

Recently, a number of reports have identified elevated expression of the human Piwi homolog–called Hiwi–in a variety of human cancers, including gastric cancer, pancreatic cancer, gliomas and, most relevant for
Read More…