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Human embryonic stem cells implanted into mice specifically engineered to have a serious retinal dysfunction resulting in blindness have restored the animal’s capacity to sense light during tests.
The results, published in international magazine, Cell Stem Cell, were obtained in the United States by a research group in the Department of Biological Structure at the University of Washington in Seattle. The study, performed by Deepak Lamba, Juliane Gust, and Thomas Reh, demonstrated that it is possible to obtain retina progenitor cells from stem cells derived from the embryo. The researchers observed, “In principle, embryonic stem
Using new stem cell technology, scientists at the Salk Institute have shown that neurons generated from the skin cells of people with schizophrenia behave strangely in early developmental stages, providing a hint as to ways to detect and potentially treat the disease early (…)
Currently, over 1.1 percent of the world’s population has schizophrenia, with an estimated three million cases in the United States alone.
The economic cost is high: in 2002, Americans spent nearly $63 billion on treatment and managing disability. The emotional cost is higher still: 10 percent of those with schizophrenia are driven to commit suicide by the
Chronic pain, by definition, is difficult to manage, but a new study by UCSF scientists shows how a cell therapy might one day be used not only to quell some common types of persistent and difficult-to-treat pain, but also to cure the conditions that give rise to them.
The researchers, working with mice, focused on treating chronic pain that arises from nerve injury — so-called neuropathic pain.
In their study, published in the May 24, 2012 issue of Neuron, the scientists transplanted immature embryonic nerve cells that arise in the brain during development and used them to make up for a
The central nervous system (CNS) contains a diverse set of neuronal subtypes, which together form the complex circuitry that regulates virtually every life function. To maintain normal body function, several systems in mammals require the simultaneous operation of a variety of neuronal subtypes, each sending different endocrine and paracrine messages to the brain. One such system is that of leptin signaling in the hypothalamus.
Leptin signaling regulates energy balance, glucose levels, food intake, and body weight. In recent work, Jeffrey Macklis, MD, Leader of HSCI’s Nervous System Diseases Program, introduced functional neurons into the hypothalami of mice with faulty leptin
A team at Keio University has used stem cells to cure mice whose hind legs were paralyzed due to spinal cord damage, the researchers reported Wednesday at a Tokyo symposium.
The team transplanted neural stem cells grown from human iPS cells.
Team leader Hideyuki Okano, a physiology professor at Keio, said it is the first time in the world in which the curative effects of “induced pluripotent stem cells,” or iPS cells, have been confirmed.
Currently, there is no effective treatment for spinal nerve damage and treatment using iPS cells gives hope of a cure.
“It is valuable that treatment using human iPS