Spinal cord injuries, resulting in permanent disability or paralysis in most cases, account for around eleven thousand new cases in the US, annually. Due to the lack of effective treatment strategies, it is considered as the most devastating of all traumatic conditions. Now, a recent study published in the journal Stem Cells reports that activation of ependymal stem/progenitor cells from injured spinal cord (epSPCi), using endogenous stem cell-associated mechanisms, may aid in rescuing neurological function, thereby reversing paralysis associated with spinal cord injuries.
Sir Martin Evans
Stem cells could aid in treating muscular sclerosis. Animal experiments have demonstrated that it is possible to stop the aggressive, chronic inflammatory response against the myelin sheath that covers nerve cells, whose destruction leads to the devastating effects of the disease, said Giancarlo Comi, the head of the Experimental Neurology Institute of the Vita-Salute San Raffaele University. A three-day meeting, which began in Stresa, on the most recent progress regarding stem cells was opened by Nobel Prize winner Martin Evans and also included some of the most important experts on the subject in the
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New hope in treating Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s Disease, an incurable neurological disease, which is particularly frequent in former soccer players, may come from stem cells. Nicholas Maragakis and his colleagues from the Johns Hopkins University of Medicine in Baltimore in the United States, have successfully conducted an important experiment in mice. In a study published in the online edition of ‘Nature Neuroscience’, the American researchers transplanted precursor cells called astrocytes, which function as support cells for neurons, into the mice with ALS. This allow the mice to survive for much longer.
A biopolymer could aid in the regrowing of nerves induced by the use of stem cells according to a new research project that gives hope to people who have been in an accident and have lost the use of one or more limbs. The procedure will enter into clinical testing in January after animal testing has been completed.
The Experimental Neurological Institute (INSPE), founded in 2005 at San Raffaele Hospital of Milan became operational with the inauguration of more than 1,200 square meters of lab space entirely dedicated to general and clinical research therapies for serious neurological diseases,
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Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible progress, measured in terms of