Tag Archives: Nature Cell Biology

Researchers Map Human Egg and Sperm Development

UCLA stem cell researchers from the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research led by Dr. Amander Clark have developed the first biological resource that maps critical stages of human egg and sperm cell development during fetal life.

The resulting map has important implications for future research of infertility, such as for cancer survivors left unable to create eggs or sperm due to chemotherapy or radiation treatment. Another important result of this research is a better understanding of the cellular origins of testicular cancer, which is believed to begin in males during fetal life.

“Housekeeping” Mechanism for Brain Stem Cells Discovered

Researchers at Columbia University Medical Center (CUMC) have identified a molecular pathway that controls the retention and release of the brain’s stem cells. The discovery offers new insights into normal and abnormal neurologic development and could eventually lead to regenerative therapies for neurologic disease and injury. The findings, from a collaborative effort of the laboratories of Drs. Anna Lasorella and Antonio Iavarone, were published today in the online edition of Nature Cell Biology.

The research builds on recent studies, which showed that stem cells reside in specialized niches, or microenvironments, that support and maintain them.

“From this research, we knew that
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