“Latest Stem Cells News”

In the near future, hearts that have just suffered a heart attack will be able to repair themselves, according to an incredible discovery of how to reeducate cardiac stem cells to repair damaged hearts. In fact, stem cells normally perform the delicate task of repairing cardiac muscle, but after a heart attack the cells no longer carry out this highly important self-repair.

Italian scholars at the ‘Sapienza’ University in Rome and the European Molecular Biology Laboratory (EMBL) in Monterotondo, have discovered why these cells stop functioning correctly, and now understand how to induce them to repair damage from heart attacks. The announcement was made during the 69th Congress of the Italian Society of Cardiologists in Rome by Professor Antonio Musaro’ of the ‘Sapienza’ University in Rome.

Musaro’ said, “With our studies conducted together with Doctor Nadia Rosenthal of the EMBL we have learned why stem cells present in the heart after damage from a heart attack or trauma, do not correctly function. In fact, instead of producing functional contractile tissue that allows the damage to be ‘repaired’, they stop functioning or even produce non-functional fibrous tissue. This occurs because the heart attack or damage creates an environment that is hostile to normal stem cells activity.”

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A 41-site clinical trial, testing the restorative effect that adult bone marrow stem cells have on damaged or injured myocardium in heart attack patients, is being led at Wake Forest Baptist by Sanjay Gandhi, MD.

Phase I of the research study found that stem cells derived from bone marrow (mesenchymal stem cells) were safe for patients and may have the ability to limit scar formation, improve heart function and preserve tissue following a first heart attack.

Phase I was a multicenter study of 53 patients which demonstrated that the treatment was safe in adults, and those patients given this stem cell therapy actually experienced improvement in their overall ejection fraction. The earlier phase of the study showed that these mesenchymal stem cells could target the damaged myocardial tissue and initiate a process for recovery of heart muscle that could hopefully result in improvement of the overall heart.

Wake Forest is currently participating in a Phase II multicenter study investigating the efficacy of a one-time infusion of adult bone marrow stem cells in heart attack patients. Patients who experience a first time heart attack and undergo coronary angioplasty and stenting are eligible. Investigators are studying whether treatment with stem cells results in less heart muscle damage and improved heart function following a heart attack.

Wake Forest Baptist is the only trial site in North Carolina, South Carolina, Virginia and West Virginia.

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Fat around the waist is commonly seen as a contributing factor to heart attack. Ironically, a company is now testing whether adult stem cells from fat could help prevent long-term damage after a heart attack.

A new medical team is now investigating whether adult stem cells harvested from a person’s own fat, delivered shortly after a heart attack, could prevent some of the cardiac muscle damage that results from blocked arteries.

During a heart attack, blood vessels that deliver blood to the heart muscle are blocked. The lack of oxygen slowly kills the tissue. San Diego-based Cytori Therapeutics has developed a treatment that aims to prevent much of that muscle damage before it starts.

The procedure involves injecting concentrated slurry of adult stem cells and other regenerative cells isolated from the patient’s body directly into the heart’s main artery within 24 hours after an attack.

“Time is muscle. The quicker you get in, the better,” Christopher Calhoun, Cytori’s chief executive officer says. “You can’t do anything about dead tissue, but tissue that’s bruised and damaged-that’s revitalizable. If you can get new blood flow in there, that tissue comes back to life.”

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A new research has suggested that cardiac stem cells - even in elderly and sick patients – could generate new heart muscle and vessel tissue and be used to treat heart failure.

Scientists surgically removed tissue from the muscular wall of the heart’s chambers in 21 patients.

They then isolated and multiplied the cardiac stem cells (CSCs) found there.

Most of the patients had ischemic cardiomyopathy (enlarged and weakened muscle due to coronary artery disease). Eleven also had diabetes. The average age of patients was about 65.

“Regardless of the gender or age of the patient, or of diabetes, we were able to isolate in all of them a pool of functional cardiac stem cells that we can potentially use to rescue the decompensated human heart,” said Domenico D’Amario, author of the study and a postdoctoral fellow at the Center for Regenerative Medicine at Harvard, Boston, Mass.

The study has been presented at the American Heart Association‘s Scientific Sessions 2010. (ANI)

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Another congestive heart failure patient has been helped by stem cell research using adult stem cells. Terry Areford, 62, a multiple heart attack victim has been given a 2nd chance at life after receiving Vescell stem cell treatment to heal his heart muscle in Thailand.

Congestive Heart Failure Symptoms

Terry was dying. He was slowing down. He had the usual symptoms of congestive heart failure. He had shortness of breath. He could barely walk 50 feet slowly. However, Terry still had hope. His daughter came across the Vescell website and contacted them.

Adult Stem Cells From Your Own Blood

For those of you unfamiliar with Vescell stem cell therapy in Thailand, it is a process created by a company called Theravitae in which adult stem cells are removed from the patient’s blood (similar to a blood donation) and then multiplied into a therapeutic dose and then implanted into the patient’s heart muscle and/or coronary arteries.

But back to Terry’s stem cell story-

Before Vescell Treatment

• Ejection Fraction 10%
• Could barely walk
• Severe shortness of breath

After Adult Stem Cells Implanted

• Ejection Fraction at 45%
• Plays 3 rounds of golf per week
• No shortness of breath- outside chopping firewood

3 full 18 hole rounds of golf per week? No kidding Terry?  I am very happy for you.   Like many of the Vescell heart patients recently, Terry has become an adult stem cell advocate and wants other congestive heart failure patients to know that there is still hope out there.

You are welcome to call or email Terry  at 304-594-9377 or his email is bkareford@msn.com

Stem Cell Research in Thailand

This is the third stem cell research success story to come out of Thailand in the last month. See stories from heart attack victims and heart failure patients James Eilert and Andy Jordan as well.   Is anyone in the FDA paying attention to this?  Adult Stem Cells can be used now to help these heart patients with no side effects!  Why do they have to leave the United States for it?

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In the Dominican Republic, Dr. Zannos Grekos, a stem cell research doctor, is now helping patients with heart disease and lung diseases with their own Adult Stem Cells as reported on CNN in a special research report.

Adult Stem Cells Helping Heart Disease and Lung Disease

In the last 18 months, Dr. Grekos and his company Regenocyte have treated more than 100 patients for either heart diseases such as congestive heart failure, coronary artery disease, heart attacks, and angina and lung diseases such as pulmonary hypertension, emphysema and COPD.

The story features Barbara McKean of Naples, Florida. Barbara was suffering from the lung disease, COPD and was treated with her own stem cells.

From the stem cell article:
“Right away, the next morning, I felt a sense of well-being that I hadn’t felt in a long, long time,” McKean said.

“I know that I am living proof that this does work,” she added. “I know that.”

His Eyes Are Wide Shut

Check out this quote from the chief medical officer of the American Lung Association-

The chief medical officer of the American Lung Association, Dr. Norman Edelman, said he does not doubt the sincerity of patients who believe they have been helped by stem cell therapy. But he added, “There’s an enormous placebo effect in almost all of these cases.”

So Dr. Edelman sees a woman, Barbara McKean, featured previously here,  who was on oxygen 24/7 walking around with a cannister and now, after stem cell treatment, is completely off oxygen and he thinks it is the placebo effect? Ridiculous.

Luckily, Barbara’s doctor does not intentionally close his eyes to the obvious:

McKean’s family physician, Dr. Robert Folsom, confirmed to CNN that she had been suffering for many years from an advanced state of COPD, an incurable lung disease. Folsom told CNN he was “quite incredulous” after seeing her condition improve.

Folsom, who said he has been McKean’s family physician for many years, disputed any suggestion that her apparent recovery stemmed from a “placebo effect” — an improvement sometimes seen in patients who are given an inert substance in clinical trials.

“I know about the placebo effect, and her improvement does not seem to be a result of that,” he said.

Stem Cell Therapy- Documenting Results

Dr. Grekos is documenting research data  from his patients treated with their own stem cells and wishes to present it to the FDA at the end of this year.

In the past few days, another stem cell research doctor, Dr. Roberto Fernandez Vina, also just presented his results of his stem cell research data for COPD and Emphysema at the annual International Society for Stem Cell Research annual meeting.

And Dr. Grekos had a parting shot for the “experts” who always try to downplay any adult stem cell success story:

He shrugs off the criticism from people who doubt his claims, saying he — and not they — are on medicine’s cutting edge.

Stem cell experts who reject his methods “need to be better educated,” he said.

original post by Don Margolis

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