Scientists have taken the first steps toward producing the “heart patch,” a design for a medical implement used to repair damage from heart disease, a new study suggests.
Last week, researchers from Duke University presented the results of a study which, using mouse embryonic stem cells, examined the way these cells develop into heart muscle, HealthDay News reports (…)
A study on mice directed by Alessandra Sacco of Stanford University has shown that once inserted into a diseased muscle, just one adult muscular stem cell can reproduce to form an entire ‘family’ of cells and restore lost muscular function. In a leg muscle with no muscular stem cells that has been irreversibly damaged, a single adult stem cell can take root and multiply, restoring muscular function.
The study was presented today in the Annual Meeting of the American Society of Cell Biology
(ASCB) in San Francisco. The muscular stem cells in this case are called
When a muscle is damaged, dormant adult stem cells called satellite cells are signaled to “wake up” and contribute to repairing the muscle. University of Missouri researchers recently found how even distant satellite cells could help with the repair, and are now learning how the stem cells travel within the tissue. This knowledge could ultimately help doctors more effectively treat muscle disorders such as muscular dystrophy, in which the muscle is easily damaged and the patient’s satellite cells have lost the ability to repair.
“When your muscles are injured, they send out a ‘mayday’ for satellite cells to come and
Image by foundphotoslj via Flickr
CHICAGO (Reuters) – A new understanding of the genes that make muscle cells may change the way researchers think about stem cell transplants for muscular dystrophy and muscle injuries, U.S. researchers said on Wednesday.
In a surprise finding, they said genes important for forming muscle cells in embryos and newborns are not normally active in adult stem cells.
And researchers hoping to use muscle stem cells in stem-cell transplant therapies should not assume genes that control early muscle development serve the same purpose in repairing adult muscle, Christoph Lepper and colleagues at the Carnegie Institution in Baltimore