“Latest Stem Cells News”

Italian researchers have discovered new stem cells that could be potential sources of ‘spare’ neurons. A study carried out at the University of Verona has led to the discovery of Leptomeningeal Stem Cells (LeSC), a new population of stem cells located in the the meninges, which cover the entire central nervous system in mammals.

LeSCs are immature cells able to maintain themselves and differentiate into mature excitable neurons. This demonstrates that the brain has a greater regenerative capacity than what was believed until now. The results of the study, conducted on an animal model, were published recently in the Journal of Cellular and Molecular Medicine.

Incoming search terms:

The symptoms of multiple sclerosis could be reversed thanks to stem cell transplants from the patient’s own bone marrow, according to a study that will be published in March in Lancet Neurology by researchers from Northwestern University Feinberg School of Medicine in Chicago, who say that stem cell transplants could restore the immune system of patients suffering from the disease, stopping its evolution, and even causing its regression.

Multiple sclerosis is an autoimmune disease characterized by a defective immune system, which attacks the body’s own tissues in the central nervous system, and effects 57 thousand Italians. The disease develops through a process called “demyelinization”, which causes the deterioration of myelin – sheaths composed of fatty acids that cover nerve fibers – slowing or completely stopping the transmission of nerve impulses along the fibers in the brain and the spinal cord.

Promising results from a small study may offer hope for the treatment of multiple sclerosis (MS).

Researchers from the University of California – San Diego report dramatic improvement after treating MS patients with stromal vascular fraction (SVF) stem cells from a patient’s own body fat. They say the SVF therapy can limit the body’s immune system reaction and promote the growth of new myelin – the fatty “insulation” on axons in the brain, which breaks down in patients with MS.

“None of the presently available MS treatments selectively inhibit the immune attack against the nervous system, nor do they stimulate regeneration of previously damaged tissue,” Boris Minev, M.D., from the Division of Neurosurgery at UCSD, was quoted as saying. “We’ve shown that SVF cells may fill this therapeutic gap”.

Only three patients were treated in the study, but all three showed dramatic results following treatment, including improved balance and coordination and increased energy. They also say their frequent, painful seizures had stopped.

Incoming search terms:

Alex Normandin, 26, of Montreal, Canada has been cured of his Multiple Sclerosis following the implantation of his own Adult Stem Cells. The stem cell therapy was done in conjunction with a research program in Ottawa with Dr. Mark Freedman.

A medical student, Alex was diagnosed with multiple sclerosis more than 2 years ago and was distressed to learn that he had the aggressive form of MS and was on track to be in a wheelchair in a matter of months.

Process of Stem Cells for Multiple Sclerosis in Canada

Luckily, he was accepted into Dr. Freedman’s stem cell research program at Ottawa General Hospital. In this stem cell program, the patient is first given chemotherapy to kill off the immune system. Then, the stem cell transplant takes place to “reboot” the immune system.

From the stem cell article:

Normandin became patient 19. His transplant took place in December 2008. It worked.

Not only does the disease appear to have stopped its progression, but Normandin says he feels his co-ordination and strength improving.

Normandin is buoyed by the treatment’s eight-year track record — none of the 24 patients have suffered a relapse or a brain lesion. (The article fails to mention the one patient who died from the chemo)

Stem Cell Therapy in China Quote Remembered

Readers of this blog may remember Dr. Freedman from this Multiple Sclerosis Stem Cell post in which he commented on stem cell therapy in China:

Dr. Freedman is concerned that patients are forking over large amounts of money for unproven treatments like this, especially when there is no follow-up care or monitoring when they get home.

“It’s dangerous in the wrong hands,” he said. “The only reason these places could be in existence is to take people’s money and offer them something that’s unproven.”

I called that the “Most Hypocritical Statement So Far in 2009″ then, and I will stick to that for the following reasons:

1. Chemotherapy is dangerous.  1 of Dr. Freedman’s patients died while receiving it before the stem cell transplant- to call another treatment dangerous (which doesn’t use chemo, by the way) is hypocritical.
2. He says the therapies are unproven and only in existence to take people’s money-  however, in this article- it is revealed not only is his own treatment unproven, but it also is not free, in fact, far from free- “The trial procedure costs would be about $50,000 to $60,000 per patient.”  (A reader has since wrote in and says the Canadian Government pays for this treatment)
   

Actually that cost is more than other stem cell therapies in Costa Rica and China that we have covered in here (both are around $25-30,000) and do NOT use chemo.

So for those people who say that stem cell therapy overseas is very expensive– just look at Canada, or for that matter, look at Dr. Richard Burt’s multiple sclerosis study at Northwestern University in Chicago.  The cost for one multiple sclerosis patient is $90,000

I’m directing  this at critics who always point out that overseas stem cell therapies are expensive and dangerous rather than pointing out the “arrogance” of Dr. Freedman, who as far as I can tell is truly helping Multiple Sclerosis patients although he probably shouldn’t be opening his mouth about other stem cell treatments.

Stem Cell Treatment By The People, For The People

And yes, all of  these stem cell treatments in Canada, USA, Costa Rica, and China are “unproven” in the eyes of the medical world and the New England Journal of Medicine, although they all are proven in the eyes of the patients who receive the Adult Stem Cells whether they are in the form of umbilical cord stem cells (China), mixture of stem cells from the patient’s fat and cord blood stem cells(Costa Rica) and/or Adult Stem Cells given in the form of a stem cell transplant after chemotherapy (Canada, USA).   They all seem to work most of the time FOR THE PATIENTS NOW and that is what is important. Making Multiple Sclerosis patients wait for 10 years or so for the endless cycle of clinical trials in the US and Canada to end just so their doctors can see the words “proven” in a study is a travesty.

The Emergence of the Internet and Self Directed Healthcare

We can ask Jason Upshaw and friends about stem cell therapy in Costa Rica. Or, we can ask Betty Helm about how stem cell therapy in China worked for her MS. Thanks to the wonders of the internet, patients now have a bigger say and more access to information than ever before.

Dr. William Davis at the Heart Scan Blog has a great post on how health care is changing. Much like stockbrokers have disappeared due to online companies like E-trade and Ameritrade, patients can now take a more self directed approach to their health thanks to the internet.

original post by Don Margolis

Incoming search terms:

A stem cell research study showing that Adult Stem Cells taken from a patient’s fat and then implanted back into that patient, helps improve their Multiple Sclerosis. The research study documented 3 case studies of Multiple Sclerosis patients.

Case Studies of Multiple Sclerosis Patients Implanted with Fat Stem Cells

Case Study #1- 50 year old man with Relapse-remitting MS:

Before the Stem Cell Therapy:

• Multiple Seizures
• Sexual Dysfunction
• Significant Memory Loss
• Taking Multiple Medications- Solu-Medrol, Baclofen,
  Provigil, Tegretol, Trileptal, Tysabri, Vitamins, Omega-3 and Zanaflex

After the Fat Stem Cells were implanted:

• No more seizures
• Improved Sexual Function
• Improved Memory
• OFF ALL MEDICATIONS

Case Study #2- 32 year old man with Relapsing-remitting MS

This patient reported after the stem cell therapy and treatment that he now has:

1. Better Balance and Coordination
2. His Depression is gone
3. Significantly improved overall condition

Incoming search terms:

British scientists have reportedly perfected the technique for curing macular-degeneration related blindness with adult stem cells. Returning Hope, a pioneering Asian adult stem cell treatment portal, expects to be one of the first in the world to offer the treatment.

Researchers from the Institute of Ophthalmology at London’s University College used embryonic eye stem cells to replace the layer of damaged eye cells. While Pfizer is backing the British push to bring the therapy to patients, Brian Dardzinski, CEO of Returning Hope, expects that Adult Stem Cell treatments will be available both much sooner and much cheaper in Thailand.

“We have been helping patients with Multiple Sclerosis, autism, brain injury, stroke, ALS and Parkinson’s find treatment in Thailand for some time now. Overseas health care providers have been saying that there are years needed to bring these treatments to patients – we are already helping them get back to a normal life”, said Mr. Dardzinski. “We can already help patients with some eye diseases, and macular degeneration patients will join them very shortly”.

Incoming search terms: