What might become the first drug derived from human stem cells failed in two late-stage clinical trials, dealing a setback to the drug’s developer and to the stem cell field (…)
Prochymal is a preparation of mesenchymal stem cells, which are obtained from the bone marrow of healthy young adults.
Because the cells are derived from adults, they sidestep the ethical issues stemming from the destruction of human embryos needed to make embryonic stem cells. Unlike most other types of adult stem cells, mesenchymal cells grow well in culture, so thousands of doses can be produced from a single donation.
A medical model developed for regenerating bladders by using stem cells
Researchers in the United States have developed a medical model for regenerating bladders using stem cells harvested from a patient’s own bone marrow. The research, published in STEM CELLS, is especially relevant for paediatric patients suffering from abnormally developed bladders, but also represents another step towards new organ replacement therapies.
The research, led by Dr Arun Sharma and Earl Cheng from the Feinberg School of Medicine at Northwestern University and Children’s Memorial Research Center, focused on bone marrow mesenchymal stem cells (MSCs) taken from the patient. Previously studies into the
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The walls of the blood vessels could be the natural location of ‘multipotent mesenchymal’ stem cells (cells that are able to regenerate various tissues of human organs). This was discovered in an international study published in Cell Stem Cell by researchers from the Milan General Hospital Foundation, led by Lorenza Lazzari. The discovery, explained the experts, “could represent a true turning point for stem cell research.” It would give a precise location for mesenchymal stem cells, which until now has been unknown, and it would also demonstrate that multipotent stem cells do not belong to
Research has indicated that certain sarcomas come from the mesenchymal stem cells. However, expression of neural stem cells has been noted in others. Identifying and isolating mesenchymal stem cells and neural stem cells relies on finding specific proteins expressed by both types.
In this study, eight different markers representing proteins associated with these two types of stem cells were applied to the 81 tumors. Through cluster analysis, the researchers organized the data into groups showing similar patterns. Two major subgroups of pediatric sarcomas emerged
What are mesenchymal stem cells? where are they found in the human body? What are their most promising clinical applications? Gordana Vunjak-Novakovic of Columbia University gives us an answer to these questions and and an outlook on the future of mesenchymal stem cells.