Tag Archives: Mesenchymal stem cell

Stem Cells Against False Joints

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Russian scientists started clinical trials of treating false joints by means of demineralized bone matrix with introduced mesenchymal stem cells of a patient.

False joints often occur as a complication during fractures of long bones, when splinters do not adhere, and cartilage layer forms between them. This layer is called false joint, and in this case, additional surgery is required to help a bone to heal.

Modern surgeons fight this problem with bone transplants, but bone recovery takes about one year. Possible solution is transplantation of mesenchymal stem cells of bone marrow, which can turn into various cells, including
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First Stem Cell Drug Fails 2 Late-Stage Clinical Trials

What might become the first drug derived from human stem cells failed in two late-stage clinical trials, dealing a setback to the drug’s developer and to the stem cell field (…)

Prochymal is a preparation of mesenchymal stem cells, which are obtained from the bone marrow of healthy young adults.
Because the cells are derived from adults, they sidestep the ethical issues stemming from the destruction of human embryos needed to make embryonic stem cells. Unlike most other types of adult stem cells, mesenchymal cells grow well in culture, so thousands of doses can be produced from a single donation.

Stem cells,
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New study into bladder regeneration heralds organ replacement treatment

A medical model developed for regenerating bladders by using stem cells

Researchers in the United States have developed a medical model for regenerating bladders using stem cells harvested from a patient’s own bone marrow. The research, published in STEM CELLS, is especially relevant for paediatric patients suffering from abnormally developed bladders, but also represents another step towards new organ replacement therapies.

The research, led by Dr Arun Sharma and Earl Cheng from the Feinberg School of Medicine at Northwestern University and Children’s Memorial Research Center, focused on bone marrow mesenchymal stem cells (MSCs) taken from the patient. Previously studies into the
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Stem Cell–Associated Proteins Can Identify Origins of Pediatric Tumors

Research has indicated that certain sarcomas come from the mesenchymal stem cells. However, expression of neural stem cells has been noted in others. Identifying and isolating mesenchymal stem cells and neural stem cells relies on finding specific proteins expressed by both types.

In this study, eight different markers representing proteins associated with these two types of stem cells were applied to the 81 tumors. Through cluster analysis, the researchers organized the data into groups showing similar patterns. Two major subgroups of pediatric sarcomas emerged