What might become the first drug derived from human stem cells failed in two late-stage clinical trials, dealing a setback to the drug’s developer and to the stem cell field (…)
Prochymal is a preparation of mesenchymal stem cells, which are obtained from the bone marrow of healthy young adults.
Because the cells are derived from adults, they sidestep the ethical issues stemming from the destruction of human embryos needed to make embryonic stem cells. Unlike most other types of adult stem cells, mesenchymal cells grow well in culture, so thousands of doses can be produced from a single donation.
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Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible progress, measured in terms of
Cancer patients in remission at a Suffolk hospital can have their own cells transplanted back to them with the use of a new piece of equipment.
The stem-cell bath defrosts frozen cells taken from people recovering from blood cancers myeloma, leukaemia and lymphoma at Ipswich Hospital.
When transplanted back to the patient following treatment the cells can help their body create new bone marrow.
The bath cuts down on the need for patients to travel to other hospitals.
The stem cells are stored at -190C in liquid nitrogen and can be kept for several years at the national blood transfusion centre in Cambridge.
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On any given day, an estimated 6000 Americans who need a bone marrow transplant are searching the country’s donor banks hoping to find the right match.
For many of those patients, especially minorities, the odds of finding an outside donor have been pretty low. But, that is starting to change. There is new research that suggests the donor pool may be widening.
Just shy of his second birthday, little Elmor Bonilla has overcome obstacles and odds most people don’t face over a lifetime.
Elmor was born with Krabbe disease; a rare and often fatal disorder that attacks the central nervous
The ‘White Room’ at Meyer pediatric hospital in Florence needs to complete a few more procedures to become completely functional. This stem cell and cellular product ‘factory’ will allow cells to be manipulated for therapies used in bone marrow treatments against leukemia and tumors and in reconstructive medicine to reproduce bone, cartilage, fat, and nervous tissue in metabolic and neurological diseases and treatments for serious autoimmune disorders.
“The certification procedures are very long,” explained the head of transfusions and cellular therapy, Franco Bambi, “because we will be considered a pharmaceutical manufacturing facility, but we are planning to finish the