“Latest Stem Cells News”

The first-ever dental stem cell bank in India called “Store your Cells” has now been launched. This unique bank is the venture of started by dentists at Dhruv Polyclinic, Mumbai.

The venture was formed under the guidance of Dr. Kedar Gadgil, who is a successful implant dentist practising at London (UK), Kent (UK), and Mumbai . He is the Director and lead clinician of Dhruv Polyclinic.

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In a stem cell research trial that isn’t getting enough news, liver patients are now being treated with their own Adult Stem Cells at Hammersmith Hospital in London, England. They have treated more than 30 patients now with “good results.” This is good news for those liver patients facing a transplant (and death).

I covered this stem cell story back in September 2008, and since then it seems they have treated more liver patients with their own stem cells with more good results. This excerpt is from the most recent stem cell article:

The stem cells help to grow new liver cells so that a damaged liver can begin to function normally again.

The team, which is based at London’s Hammersmith Hospital, has used the technique on around 30 patients so far with good results. They hope the treatment will become mainstream within three to five years.

It involves taking blood from patients, removing stem cells that circulate in the bloodstream and multiplying them in a laboratory. They are infused back into the liver via a main artery where they continue to multiply as liver cells.

The technique, which is undergoing trials, could revolutionise treatment of patients with liver failure. At present there is no method of keeping them alive as there is with kidney disease.

The Original Is Always Better Than the Sequel

However, the original post back in September 2008, had more details about this new stem cell treatment:

Administering autologous expanded mobilized adult progenitor CD34+ cells into the hepatic artery of patients with alcoholic liver cirrhosis (ALC) leads to considerable benefit, researchers report in the September issue of the American Journal of Gastroenterology.

“We are encouraged that the majority of patients in this study experienced a significant improvement in their liver functions,” senior investigator Dr. Nagy A. Habib told Reuters Health.

Dr. Habib of Imperial College, London, and colleagues studied nine ALC patients who had been abstinent for at least 6 months. The patients underwent granulocyte colony-stimulating factor mobilization and leukapheresis. Autologous CD34+ cells were then expanded in vitro by an average of 5 times and injected into the hepatic artery.

All patients tolerated the procedure well and over 12 weeks of follow-up there were significant decreases in serum bilirubin. A significant reduction in levels of alanine transaminase and aspartate transaminase was seen 1 week after the transfusion and showed improvement through the study period.

Seven of the patients showed an improvement in Child-Pugh scores, and on imaging at 12 weeks, three patients showed a complete resolution of ascites and two had a significant reduction.

Stem Cell Therapy for Liver- Faster Please

This is fantastic news for cirrhosis patients, as well as Hepatitis C patients.  However, once again, the stem cell therapy isn’t getting to the patient fast enough.  The stem cell research trial seems to have been going on for more than 1 year, yet only 30 liver patients have been treated.  Think about all those liver patients who can probably be improved by this and safe as well- nothing to lose.

(original post by Don Margolis)

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Barbro Lowed, a retired air hostess from London, England says that stem cell research using Adult Stem Cells removed from her bone marrow has given her her life back.  Barbro had previously been suffering from congestive heart failure before the stem cell treatment. The heart failure was caused by a faulty valve.

This research story starts with Barbro going into congestive heart failure because of a leaky heart valve.  Then in Barbro’s own words -

Unless it was repaired, my heart would steadily worsen, until it couldn’t function any more. Even though I needed the operation straight away, the NHS waiting list was two years, which really worried me.

After six months, with no sign of an operation date, I was getting desperate. I felt dizzy and lethargic all the time and couldn’t even walk to the local shops without struggling for breath.

When Free Health Care Isn’t Free Anymore

Ok, I will give the US FDA a day off and target Socialist (Free?) Healthcare today. Can you imagine needing an operation yesterday and having to wait 2 years?  That is shameful.   And this is what Obama has in mind for us? I hope not. But no more ranting- on with the stem cell story….

Finding A Stem Cell Doctor Who Used Her Own Adult Stem Cells

Barbro found Professor Andreas Zeiher in Germany who had been performing stem cell therapy using the patient’s own Adult Stem Cells for many years. Now this is where the story gets a little confusing (at least to me):

Stem Cell Therapy for Congestive Heart Failure

According to Barbro’s account, Dr. Zeiher implanted the stem cells into her heart valve which apparently improved both her valve and her congestive heart failure. But if you look at the article, then in part 2, Dr. Zeiher describes implanting the stem cells into the arteries to cure the heart failure and in turn the heart valve?

Very confusing, but the most important part of the story is that Barbro now has her life back thanks to being implanted with her own Adult Stem Cells.

How Do the Stem Cells Do That Thing They Do?

Also from the article is this interesting tidbit from Dr. Zeiher: Stem cells have this extraordinary ability to turn into other cells. They help the heart heal by encouraging the formation of new blood vessels, which brings more oxygen and nutrients to the heart muscle.

And as far as we know, unlike drug treatments, stem cell transplants have no undesirable side-effects. The process is also less risky than conventional open-heart surgery, as it doesn’t involve a general anaesthetic, which is always a concern with a heart failure patient.

You can read the full article here as it is very fascinating-  Stem Cell Research Article

This is the 2nd day in a row with a Heart Disease story helped by Stem Cell Research using a patient’s own stem cells. Yesterday we featured a Michigan man who also suffered from congestive heart failure.

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It works in racehorses. Who knows if it’s possible in humans. A technique using stem cells to repair damage to the Achilles tendon is about to be tested in Great Britain.

British biotech company MedCell Bioscience has announced that it will begin human testing in the next six months and expects to perform a broad study in various European hospitals in 2011.

Patients will receive injections containing millions of their own stem cells extracted and multiplied in the lab to regenerate damaged tissue. Over 1,500 racehorses have been treated with the same procedure and the results have given researchers a reason to be optimistic. They indicate a 50% reduction in relapses in the next three years compared to conventional treatments.

“The passage from the veterinary clinic to human medicine is uncommon,” said Nicola Maffulli, an Italian orthopedic surgeon known as the ‘tendon king’, an expert in sports medicine who has been living in England for years. Maffulli will be collaborating in the human testing. “Normally testing goes the other way.” Stem cell therapy to repair damage to the Achilles tendon has become very popular in racehorses, where animals worth millions of dollars race against one another. The technique was used for the first time by surgeons at the Royal Veterinary College in London.

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Progress has been made against strokes thanks to stem cells. British researchers, thanks to these cells, have managed to repair brain tissue damaged by a stroke. The study, financed by the research council on biological and biotechnological sciences of the United Kingdom, was published in Nature Biomaterials. The team from the Institute of Psychiatry at the University of Nottingham, used a biodegradable polymer called Plga to build a scaffold for neural cells.

Using these they filled the cavity left by a stroke. This allows, explained Mike Modo, psychiatrist at King’s College in London and coordinator of the study, “stem cells to create connections with the other cells, contributing to the re-stabilization of the damaged tissue”. One of the main obstacles for scientists has been overcome in this way: normally, stem cells do not find any support in the cerebral area affected

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Memorial Hermann-Texas Medical Center in Houston announced this morning it has done the nation’s first stem cell transplant to successfully treat a stroke patient.

The patient came to the hospital last Wednesday, too late to receive clot-busting drugs to treat the stroke, according to a news release about the procedure. So doctors decided to try a therapy they are investigating as part of a clinical trial with the University of Texas Medical School at Houston: using stem cells from the patient’s own bone marrow. The adult stem cells — not controversial embryonic stem cells — came from marrow in the patient’s leg. The theory of how they work is that the stem cells migrate to the area of injury in the brain to do repairs, according to the release.
“The patient is recovering remarkably well and has not shown any signs of paralysis,” the release says. “He remains in the hospital under observation, but will be discharged later this week.”

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