HOLLAND – Stem cells to create intestinal epithelium

Posted on 27 October 2011 by Stem Man

: Image by RiffRaff via Flickr

Artificial intestines could be created thanks to stem cells. Intestinal stem cells grown in the laboratory have been manipulated to differentiate in order to produce all of the different types of cells that form intestinal epithelium, said a Dutch study, published in ‘Nature’ magazine by Hans Clevers of the Hubrecht Institute in Utrecht.
The study also outlines a more precise link between stem cells and their microenvironment.

It also offers a practical technique to generate new intestinal epithelium in the laboratory. Stem cells, which express the Lgr5 protein, were discovered on several specific regions of the intestinal epithelium, called crypts.
Clevers and his colleagues describe a long-term method transform single stem cells in culture that express Lgr5 in structures simulating the environment of the organ, which contain all of the different types of differentiated cells present in the intestinal crypts.

Incoming search terms:

baldness research2013, Is zell-v good for cancer, biobank clevers, chrons disease stemcells, fibro research2013, hans clevers ppt, intestine AND STEM and clevers, micro colitis treatment for cottontop monkeys, stem cells in intestine ppt.

New Stem Cells Therapy Treating Crohn’s Disease

Posted on 15 September 2011 by Stem Man

Cellular therapy with stem cells is revolutionizing the focus of treatment of many serious diseases. Replacing the cells of damaged tissue with other new cells from the same patient is already a reality. This is the basis of cellular therapy and regenerative medicine, the latest great advance in biomedicine.

In this line, Hospital Clínic, Barcelona is exploring an innovative cellular therapy that uses stem cells to treat Crohn’s disease, a chronic genetic disease that affects 1% of the population in Spain and which has considerable impact on the quality of life of the patients. The procedure is based on an autologous bone-marrow transplant (when patients receive a transplant of their own stem cells) and now constitutes a treatment option to cure an intestinal disease that sometimes does not successfully respond to drugs and requires highly complex surgery that does not provide a cure.

With this therapy, in an average follow-up period of 6 years, 80% of transplant patients are in a phase of total remission of the disease and the remaining 20% have shown considerable improvement following the transplant, and are now responding favorably to drugs.

Dr. Julián Panés and Dr. Elena Ricart over the Gastroenterology Department of Hospital Clínic, Barcelona are the driving force behind this therapy in Spain and began to implement regenerative cellular therapy in patients with Crohn’s disease in August 2008. To date, a total of 6 patients are benefiting from this new treatment, of whom 3 have already completed the process and are in the follow-up face, and a further 3 are at different stages of therapy. The transplant requires several weeks of admission to hospital before patients receive their own cells.

Continue reading →

Incoming search terms:

stem cell ppt, stem cell therapy ppt, latest crohns research 2013, morbus crohn current research, stem cell therapy morbus crohn, research morbus crohn, stem cell therapy for crohns disease, crohns disease ppt, latest news for chrons desease, morbus crohn cure, Latest Crohns Therapy, Ulcerative colitis latest, newest advances against crohns in 2012, sickle cell anemia treatment, recent advancements for the cure of ulcerative colitis, Progress in treating Morbus Crohn, ulcerative colitis ppt, stem cell clinic for colitis, stem cell research ulcerative colitis, stem cell therapy for crohns 2012, stem cell therapy ulcerative colitits, stem cell transplant procedure for crohns disease, stem cell transplants and chrons, stem genex and crohn\s disease, tretment and follow up for morbus crohn, new treatment 2013 for morbus crohns, morbus crohn stenose symptoms, crohn\s disease latest research2013, crohns research 2013, crohns human stem cell treatment, crohns cure research 2013, crohns 2012 latest treatment, colitis cure treatment stem cells london, August 2012 Regenerative Repair Advances, advances in tissue replacement for Chrons Disease, cure for crohns2013, current advances in ulcerative colitis 2013, morbus crohn research, crohns 2013 research, medical treatment therapy ppt, latest treatment advances for Chrons, latest research for Crohns disease, lastest crohns therapy, ips cells are stem cells that have been resetstem.

Stem Cells: breakthrough in artificial human organ transplant

Posted on 19 December 2010 by Stem Man

Researchers for the first time have been able to demonstrate fully functional complex tissues of human organs i.e. intestines, obtained using stem cell technology, which finds applications in laboratory research as well as medical purposes. The paper was published in the journal Nature.

“This is the first study to demonstrate that human pluripotent stem cells in a petri dish can be instructed to efficiently form human tissue with three-dimensional architecture and cellular composition remarkably similar to intestinal tissue,” said Dr. James Wells, a leading researcher at the Medical Center’s Children’s Hospital of Cincinnati. “The hope is that our ability to turn stem cells into intestinal tissue will eventually be therapeutically beneficial for people with diseases such as necrotizing enterocolitis, inflammatory bowel disease and short bowel syndromes,” – he added

Stem cells have been of great interest to scientists and doctors, as they have the ability to transform into any cell type in the body, which are of more than 200 types. Unfortunately, the adult body is almost devoid of these cells, and a significant number are formed only at the stage of embryonic development. For this reason, in recent years a number of methods have been developed for producing cells with the properties of stem cells from tissues of the adult human body. These cells, called induced pluripotent, are obtained by reprogramming of skin cells.

Continue reading →

Incoming search terms:

celltex/human biostar, stem cell human organ, artificial organ cost, stem cell organ growth cost, stem cell organ growth, stem cell in organ transplant, prosthetic human organ replacement ppt, embryonic stem cells organ transplant ppt, breakthrough stem cell transplant, artificial organs ppt, stem cells growth.