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Using skin cells from people with type 1 diabetes, researchers were able to produce cells that made insulin in response to changing blood sugar levels, though not as efficiently as normal insulin-producing cells do. (…) “This is a big deal,” said Susan Solomon, CEO of the New York Stem Cell Foundation, which provided some of the funding for the study. “Tackling the basic biology of type 1 diabetes, which is a very complex disease, is a critical step. With these cells, we can see in a dish what’s happening to the immune system, and if
In a landmark paper, researchers at Stanford University have described a new way to derive human induced pluripotent stem cells (iPSCs) without the use of contaminating mouse feeder cells. Using adipose cells as the starting cell population and mTeSR1, a defined medium that allows the expansion of human embryonic and induced pluripotent stem cells without the use of feeders, the researchers were able to fully reprogram the cells to the pluripotent state.
mTeSR1 is a fully defined medium and is the most widely used feeder-independent method for culturing human pluripotent stem cells, with citations in more than 25 publications.
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One factor, not four like a majority of biologists throughout the world have said up until now, is sufficient to convert an adult stem cell into a cell that is similar to an embryonic stem cell. A recipe that is much more simple than what the scientific community has believed has been discovered by Hans Schöler and his colleagues, who include Italians ,Vittorio Sebastiano and Luca Gentile, from the Max Planck Institute for Molecular Biomedicine in Germany. The study, published in February’s edition of Cell, shows for the first time that nerve stem cells taken from
With the motto Advancing Science to Heal the World the BU stem cell scientists who founded the Center for Regenerative Medicine(CReM) could be pegged as starry-eyed idealists or scientific superheroes. Or perhaps a bit of both.
CReM codirectors Darrell Kotton, Gustavo Mostoslavsky, and George Murphy have established themselves as venturesome researchers who are willing to share their discoveries with almost anyone. And they do it for free—bucking the prevailing trend to patent, publish, and protect scientific breakthroughs. The trio’s “open source biology” is just one of the things they teach to the next generation of stem cell researchers at CReM.
(…) At the age of 29, Bhoir underwent a surgery to correct deformity in his legs. Although the limb length improved, there was no change in muscle strength. He then decided to consult Dr Pradeep Mahajan to be treated by stem cell therapy.
“A personalized treatment protocol was prepared comprising of 1 session of autologous cellular therapy combined with physiotherapy, yoga and diet modifications.