“Latest Stem Cells News”

Maria Grazia Roncarolo

It was stunning to see them closed inside of those plastic bubbles, kept far from all external contact because their immune system does not react against any foreign antigens. Today scientists can say that ADA-SCID (adenosine deaminase deficiency), a serious combined immunodeficiency caused due to a lack of the adenosine deaminase enzyme, has been definitively defeated by gene therapy developed at San Raffaele of Milan.

The final study, which combined the conclusions of clinical studies, which began in 2000 on strategic therapies developed by the HSR-TIGET (San Raffaele Telethon Institute for Gene Therapy) group, led by Maria Grazia Roncarolo and Alessandro Aiuti, and was published in the New England Journal of Medicine.

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It was stunning to see them closed inside of those plastic bubbles, kept far from all external contact because their immune system does not react against any foreign antigens. Today scientists can say that ADA-SCID (adenosine deaminase deficiency), a serious combined immunodeficiency caused due to a lack of the adenosine deaminase enzyme, has been definitively defeated by gene therapy developed at San Raffaele of Milan.

The final study, which combined the conclusions of clinical studies, which began in 2000 on strategic therapies developed by the HSR-TIGET (San Raffaele Telethon Institute for Gene Therapy) group, led by Maria Grazia Roncarolo and Alessandro Aiuti, and was published in the New England Journal of Medicine.

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Researchers using stem cells must work to make their treatments safer after a 17 year-old boy with a rare genetic disease in 2001 was cured with an embryonic stem cell transplant in Moscow, but then developed benign brain and spinal tumors four years later. According to ‘Plos Medicine’ magazine, Israeli doctors removed cancer from the boy, the tumors developed due to a stem cell treatment that he received.

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Some Steamboat Springs residents are forgoing the Tooth Fairy, hoping their teeth wind up being worth much more than a quarter.
Steamboat Springs oral surgeon Dr. John Lupori offers patients the chance to store the stem cells in the teeth he extracts. Lupori partners with StemSave, a New York-based company that freezes and stores stem cells found in the pulp at the base of teeth. Science is moving fast, those involved said, and the cells might someday save the patient’s life.

“Potentially, they’re incredibly miraculous,” said Dr. Bob Pensack, who had his daughter, Miriam, save her cells. “They’ve already been miraculous in the lab.”
Stem cells exist throughout the body and differentiate into organs and tissue. Stem cells that could be used to grow new organs, for example, are the type that haven’t differentiated. Dental stem cells fall into this category, StemSave CEO Art Greco said.

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Apparently it looks like a simple tea bag but in reality it’s a genetically engineered concentrate able to completely revolutionize treatments for stroke patients. A special little bag called ‘CellBeads’ contains tiny capsules, each containing about 1 million stem cells. Thanks to genetic engineering techniques, stem cells taken from the bone marrow are transformed into a drug that protects brain cells from dying. This allows the cells to be rejuvenated and repair damage caused by the stroke. The stem cells are encapsulated to ‘fool’ the immune system, avoiding a rejection by the body. ‘CellBeads’ were developed by a group of British scientists from the Biocompatibles International Company, and are about 2cm, which allows them to be easily removed.

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Bone marrow stem cells self transplant can reduce Multiple Sclerosis (MS) symptoms, and make the disease regress in some cases.
These are the hopeful results from a research on 21 patients diseased by MS, made by the Chicago Northwestern University School of Medicine and published on Lancet Neurology. “Since 3 years from self transplant all the patients watch their conditions better.”

Since these results, doctors decided to make a bigger research involving more MS diseased people and comparing new therapy’s results with olds’ ones.
The experiment is about taking marrow stem cells and then treating them to remove ill lymphocytes which attack nerve fibers and then causing MS.

Stem cells are ready to create a ‘correct’ immune system and transplant begins after this process. “Time factor” is the nodal point for stem effectiveness because “operating soon we can make the most of the body’s self-regeneration, which can be lost in the long run”. Anyway scientists say also “it’s not the final cure to MS”.

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