Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.
The findings, published in the May 1 issue of Genes and Development, provide a new understanding of how radiation impacts cellular and molecular processes, but perhaps more importantly, they suggest new possibilities for improving hematopoietic stem cell regeneration in the bone marrow following cancer radiation treatment.
Ionizing radiation exposure – accidental or deliberate – can be fatal due to widespread destruction of hematopoietic stem cells, the
World stem cell leaders will converge on Promega’s BioPharmaceutical
Technology Center in Fitchburg, Wisconsin, on April 30 for the 9th
Annual Wisconsin Stem Cell Symposium: From Stem Cells to Blood.
Coordinated by the nonprofit BioPharmaceutical Technology Center Institute, the University of Wisconsin-Madison Stem Cell and Regenerative Medicine Center
and the UW-Madison Blood Research Program, this year’s symposium is
focused on how the stem cells that give rise to blood develop and
It will also look at the diversity of insights stem cell
studies have provided other fields.
Highlighted topics include genesis and regulation of progenitor cells
and hematopoietic stem cells, stem cell genomes/epigenomes, stem cell
microenvironment, and tumor initiating
‘Yet again the Lazio region risks missing a chance to be at the cutting edge in the country for the therapeutic use of hematopoietic stem cells, a technique that is scientifically tested and proven in terms of its efficiency,’ said Luigi Canai, the President of the Lazio Health Commission, in a statement.
‘For days the media has been reporting important progress achieved in this field of research both abroad and in Italy. Regarding this subject, a year ago on February 19 2009, the commission chaired by me approved a unified text for a law that was later approved by
Italy is the top country in the world for hematopoietic stem cell transplants per million inhabitants, said Alessandro Nanni Costa, the director of the National Transplant Center (CNT), presenting data today in Rome from a study by the Welfare Minister on umbilical cord stem cells.
Italy boasts a registry of 370,000 healthy adults available to donate blood stem cells.
The units of umbilical cord blood preserved in Italian biobanks number 17,503, while in 2008, only 141 were used in Italy or abroad.
The objective is to reach 80,000-90,000 units of umbilical cords preserved from which blood stem cells can be removed
Gerhard Bauer & Jan A. Nolta
A new experimental technique in the future will remove skin cells from HIV patients, manipulate the cells bringing them to a state similar to that of stem cells, and then re-implant them in the same patient to eliminate the virus. The technique is still in the experimental phase in mice, but according to Gerhard Bauer, presenting the initial results of his study today at the 50th American Society of Hematology Congress in San Francisco, it’s a possibility. Bauer has been working for more than 10 years on this technique together with