Tag Archives: Hematopoietic stem cell transplantation

Stem cells: bone marrow transplants (BMT)

Early September 2016, on a late evening I received a call from the E.R (Emergency Room) that a young 18 year old boy’s family was seeking an emergency opinion from a hematologist for their son.

He was found to have severe pancytopenia [severe reduction of all three cell lines –Hemoglobin (Hb), white blood cells (WBCs) and platelets] noted on a blood count (CBC) done for progressive fatigue over a month, and new onset rashes all over his body since a day.

His evaluation revealed a related rare disorder of the bone marrow, called severe aplastic anemia (SAA), that occurs due to
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Indian doctors cure thalassaemia using stem cells

When others of her age played with dolls, eight-year-old Thamirabharani was taking blood transfusions.
Born with thalassaemia, she has, however, found hope. She was detected with the disease when she was a year and a half and has been undergoing regular blood transfusions since.

Haematologist Revathy Raj and his team from Apollo Gleneagles hospital in Chennai gave a new lease of life to the little girl from Coimbatore through stem cell transplantation. Doctors said she is now fully cured and has not needed a single transfusion since March.

Doctors claimed this is the first success story in India using the stem cells
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Stem Cell Therapy without Stem Cell Transplants

Transplantation of hematopoietic stem cells has been widely used as an approved treatment of leukemia, lymphoma and certain autoimmune conditions for the past fifty years. Other adult stem cells have demonstrated safety and efficacy in pre-clinical research and clinical trials. Mesenchymal stem cell transplants have been most widely studied in animals, especially horses & dogs, and humans. Many of these studies have focused on skeletal-muscular effects.

There is significant support for safety and efficacy in osteoarthritis, including cartilage regeneration, pain and inflammation reduction as well as recovery of function using intra-articular MSC injections. There are fewer studies of neural stem
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Blood Vessel Cells Are Key to Growing Unlimited Amounts of Adult Stem Cells

Howard Hughes Medical Institute (HHMI) scientists have discovered that endothelial cells, the building blocks of the vascular system, keep blood stem cells dividing healthily in a lab dish much longer and more effectively than previous methods of growing the cells. The new advance dramatically improves scientists’ ability to manufacture large quantities of authentic adult blood stem cells, which may help revolutionize the field of bone marrow transplantation.

Shahin Rafii, an HHMI investigator at Weill Cornell Medical College in New York City, and his colleagues report on the development of an endothelial cell platform that supports self-renewal of the blood stem
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Stem Cells – Bone marrow can cure blood disorders

A leading specialty hospital has demonstrated that bone marrow stem cells can cure blood disorders like leukemia, thalassemia and aplastic anemia, a bone marrow failure.

“Bone marrow transplant has emerged as an effective cure for cancerous and genetic blood diseases through transfusion of its stem cells from a healthy donor to an affected patient,” Narayana Health City consultant hematologist Sharat Damodar told reporters here Tuesday.

The corporate hospital in the city’s southern suburb claims to have performed about 300 bone marrow transplants with over 80 per cent success rate.
Bone marrow can be collected from a related donor (siblings), matched unrelated donor

(non-family
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