Transplantation of hematopoietic stem cells has been widely used as an approved treatment of leukemia, lymphoma and certain autoimmune conditions for the past fifty years. Other adult stem cells have demonstrated safety and efficacy in pre-clinical research and clinical trials. Mesenchymal stem cell transplants have been most widely studied in animals, especially horses & dogs, and humans. Many of these studies have focused on skeletal-muscular effects.
There is significant support for safety and efficacy in osteoarthritis, including cartilage regeneration, pain and inflammation reduction as well as recovery of function using intra-articular MSC injections. There are fewer studies of neural stem
Howard Hughes Medical Institute (HHMI) scientists have discovered that endothelial cells, the building blocks of the vascular system, keep blood stem cells dividing healthily in a lab dish much longer and more effectively than previous methods of growing the cells. The new advance dramatically improves scientists’ ability to manufacture large quantities of authentic adult blood stem cells, which may help revolutionize the field of bone marrow transplantation.
Shahin Rafii, an HHMI investigator at Weill Cornell Medical College in New York City, and his colleagues report on the development of an endothelial cell platform that supports self-renewal of the blood stem
A leading specialty hospital has demonstrated that bone marrow stem cells can cure blood disorders like leukemia, thalassemia and aplastic anemia, a bone marrow failure.
“Bone marrow transplant has emerged as an effective cure for cancerous and genetic blood diseases through transfusion of its stem cells from a healthy donor to an affected patient,” Narayana Health City consultant hematologist Sharat Damodar told reporters here Tuesday.
The corporate hospital in the city’s southern suburb claims to have performed about 300 bone marrow transplants with over 80 per cent success rate.
Bone marrow can be collected from a related donor (siblings), matched unrelated donor
(…) Participation in this drive and thus registration with the National Marrow Donor Program consists of simple swabs of the cheeks using Q-tips for a DNA test. DNA information is entered into this lifesaving donor program database. If a potential donor is identified as a potential match for David or someone else in need, he/she will be contacted by the donor program to have a small amount of blood drawn for lab testing.
If that person is then confirmed as a match, he/she will be asked to provide stem cells through a simple donation procedure where blood is taken
Image by The Library of Congress via Flickr
Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible