“Latest Stem Cells News”

Adipose Stem Cell Heart Attack Trial Data Published in Journal of the American College of Cardiology; Cytori’s APOLLO Trial Demonstrated Safety & Feasibility and Improvements in Cardiac Function

Cytori Therapeutics announced today the publication of previously reported six-month outcomes from APOLLO, the Company’s European clinical trial evaluating adipose-derived stem and regenerative cells (ADRCs) in patients with acute myocardial infarction (heart attack or AMI), as Research Correspondence in the Journal of the American College of Cardiology. The APOLLO trial was a 14-patient, prospective, randomized, double-blind, placebo-controlled, feasibility trial (Phase I/IIA) evaluating autologous ADRCs extracted with the Company’s proprietary Celution® System for the treatment of patients suffering from acute myocardial infarction.

In the APOLLO trial all patients were treated with standard-of-care and subsequently underwent an abdominal liposuction. Each patient’s adipose tissue was processed by the Celution® System where ADRCs were extracted, washed and concentrated into a syringe of clinical grade cells. Within 36 hours of the myocardial infarction and no longer than 24 hours after undergoing percutaneous coronary intervention, patients received an injection of either 20 million ADRCs (n=10) or a placebo (n=4).

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Scientists have taken the first steps toward producing the “heart patch,” a design for a medical implement used to repair damage from heart disease, a new study suggests.

Last week, researchers from Duke University presented the results of a study which, using mouse embryonic stem cells, examined the way these cells develop into heart muscle, HealthDay News reports (…)

from http://www.privatemdlabs.com/news/Heart_Health_and_Cholesterol/Mouse-stem-cell-study-examines-heart-repair$19405309.php

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“For centuries, scientists have known that certain animals can regenerate missing parts of their bodies. Humans actually share this ability with animals like the starfish and the newt. Although we can’t replace a missing leg or a finger, our bodies are constantly regenerating blood, skin, and other tissues.

The identity of the powerful cells that allow us to regenerate some tissues was first revealed when experiments with bone marrow in the 1950s established the existence of stem cells in our bodies and led to the development of bone marrow transplantation, a therapy now widely used in medicine.

This discovery raised hope in the medical potential of regeneration. For the first time in history, it became possible for physicians to regenerate a damaged tissue with a new supply of healthy cells by drawing on the unique ability of stem cells to create many of the body’s specialized cell types (…)”

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Viet Nam’s National Hospital of Pediatrics in Ha Noi this morning announced the initial success of its first stem cell therapy treatment of epidermolysis bullosa (EB), making it only the second medical institution in the world to successfully treat this genetic skin disease in this manner.

Children with EB lack a protein that anchors the outer layer of skin to the body, resulting in very fragile skin that peels off with minor friction or trauma. They suffer painful wounds and infections which eventually are fatal.

The four-year-old boy who underwent the bone marrow transplant received tissue taken from his sister, aged 10, on September 16, to stimulate the production of healthy skin cells.

Nguyen Viet Anh had a severe form of EB, which caused his toes to stick to each other and skin to peel off the inside of his mouth, said hospital director Nguyen Thanh Liem.

“It is a very complicated technology but we are happy that the donor’s bone marrow tissue has taken in his body,” he said.

Anh’s white cell count has increased to a normal level 40 days after the transplant from almost zero. The area of affected skin is now only 7 per cent of the body, a big progress from 23 per cent before the transplant.

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Doctors hope a Nottinghamshire boy with leukaemia can undergo a stem cell transplant in May.

Roman Cusick, from Calverton, is currently recovering from chemotherapy.

If he is deemed to be well enough, he will receive cells from an umbilical cord from a German donor in a procedure at Sheffield Children’s Hospital.

In February almost 200 people in Calverton helped took part in a saliva test to see if they were a suitable match.

Leukaemia occurs when large numbers of white blood cells take over the bone marrow, leaving the body unable to produce enough normal blood cells.

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