From left to right: A normal pig heart, a pig heart after being decellularised, the pig heart prepared for recellularisation. Photos courtesy of the University of Minnesota.
In a medical first, University researchers have created a beating heart in the laboratory. Using detergents, they stripped away the cells from rat hearts until only the nonliving matrix, or “skeleton,” was left; they then repopulated the matrix with fresh heart cells.
If perfected, the technique may be used someday to generate new hearts for patients. In the United States alone, about 5 million people live with heart failure, 550,000 new cases are
A sophisticated imaging system, multi-isotope imaging mass spectrometry (MIMS), demonstrates cell division in the adult mammalian heart. Researchers were surprised to find that new heart muscle cells primarily arose from existing heart muscle cells, rather than stem cells.
Recent research has shown that there are new cells that develop in the heart, but how these cardiac cells are born and how frequently they are generated remains unclear.
In a study from Harvard-affiliated Brigham and Women’s Hospital (BWH), researchers used a novel method to identify the new heart cells and describe their origins.
The research was published today in Nature.
“The question about how
In a first, scientists, including one of Indian-origin, have used light to coax stem cells to regrow parts of teeth.
The study, led by David Mooney, a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard, is the first to demonstrate the ability to use low-power light to trigger stem cells inside the body to regenerate tissue.
The researchers used a low-power laser to trigger human dental stem cells to form dentin, the hard tissue that is similar to bone and makes up the bulk of teeth (…)
A number of biologically active molecules, such as regulatory proteins
Several cell-based therapy approaches could provide new treatments for patients with Alport syndrome, reports an upcoming paper in the Journal of the American Society of Nephrology.
“Our study opens up many considerations of how new therapies related to the use of stem cells can be devised for our kidney patients with chronic disease,” comments Raghu Kalluri, MD, PhD (Harvard Medical School, Boston, MA) (…)
The experiments provide evidence that stem cell treatments could repair the kidney defects associated with Alport syndrome. “We found that stem cells derived from adult bone marrow are equally useful as embryonic stem cells,” says