The drug metformin, a mainstay of diabetes care for 15 years, may have a new life as a cancer treatment, researchers said.
In a study in mice, low doses of the drug, combined with a widely used chemotherapy called doxorubicin, shrank breast-cancer tumors and prevented their recurrence more effectively than chemotherapy alone.
The findings add to a growing body of evidence that metformin, marketed as Glugophase by Bristol-Myers Squibb Co. and available in generic versions, could be a potent antitumor medicine.
They also lend support to an emerging theory that cancer’s ability to survive and resist therapy is regulated by cancer stem
SANUWAVE Inc., an emerging medical technology company focused on the development and commercialization of non-invasive, biological response activating devices in the regenerative medicine area, reported that scientific findings titled “Extracorporeal Shock Wave Stimulation of Osteoprogenitor Cells” were presented at the 2009 International Bone-Tissue-Engineering Congress (“Bone-Tec”) in Hannover, Germany, which was held October 9-11, 2009.
Dr. Myron Spector, PhD, Professor of Orthopaedic Surgery (Biomaterials) at Harvard Medical School, Director of Orthopaedic Research at Brigham and Women’s Hospital and Director of Tissue Engineering at VA Boston Healthcare System, was an invited guest speaker at the Conference. The
Harvard scientists at Dana-Farber Cancer Institute say they have for the first time partially reversed age-related degeneration in mice, resulting in new growth of the brain and testes, improved fertility, and the return of a lost cognitive function.
In a report posted online by the journal Nature in advance of print publication, researchers led by Ronald A. DePinho, a Harvard Medical School (HMS) professor of genetics, said they achieved the milestone in aging science by engineering mice with a controllable telomerase gene. The telomerase enzyme maintains the protective caps called telomeres that shield the ends of chromosomes.
As humans age, low
Shelley Brown was pointing toward a life of cutting-edge stem cell research. Then one day in 2010, she says, she encountered the divine.
“Something was moving, and I thought I must have hit the petri dish by accident,” said Brown, who had been trying to direct a set of stem cells toward bone cells during her Ph.D. work in biomedical engineering at the University of Michigan. “When I looked closer under the microscope, I realized the cells were beating. They had spontaneously differentiated into electrically coupled, beating heart cells. That’s when I felt at the mercy of God, and that’s
Researchers found stem cells in the ovaries of young women that have the potential to become healthy eggs. Applications of this discovery may help women have children that were once too old to or left infertile because of disease.
Natalie Melgar-Fetzer, a junior in ICS from Maryland said “It’s interesting because it can give women with reproductive problems the opportunity to have children. So many people want to have babies but can’t for whatever reason.”
Researchers have already created potentially viable eggs from these stem cells by adding a protein to them as well as a gene that makes jellyfish glow