“Latest Stem Cells News”

Patents offer the economic guarantees scientists and companies need to develop new treatments, Oliver Bruestle told Deutsche Welle. He’s at the center of a German court battle surrounding embryonic stem cell research

Oliver Bruestle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, is pushing for Germany to recognize the right to patent procedures conducted on embryonic stem cells, saying patents are the right way to ensure that scientists and companies profit from their work.

Greenpeace, however, is opposed to the patents. The organization filed suit against a patent granted to Bruestle in 1999, saying that the patenting of embryonic stem cell research could lead to an “embryo industry.” (…)

There is obviously a lot of hope and hype attached to embryonic stem cell research. Some people imagine a world full of bionic limbs and clones. Is that where the research is headed?

Stem cell research has huge potential for biomedicine mainly because there’s an opportunity to generate essentially every single type of body cell and every single type of tissue artificially in a cell culture lab. This is particularly relevant for organs which have lost their capacity for regeneration. That’s true for the nervous system and the heart as well as for insulin-producing cells. For these tissues, embryonic stem cell lines, which are really the entry point of the patent and procedure, provide a limitless source of cells. We can use these cells to generate insulin-producing cells, heart cells and brain cells in limitless numbers in a cell culture dish (…)

There’s also a lot of fear for people who envision a world full of bionic limbs and organs and clones. Is there potential for this to get out of hand?

There are quite a few misconceptions in the field. For example, we get confronted with accusations that we do research on embryos. This is, in fact, not true. The way the research is done is that there is a possibility to derive what we call embryonic stem cell lines from oocytes, which have been fertilized during artificial insemination or during fertility treatments which are left over and frozen and which are otherwise thrown away in large numbers.

There is an opportunity to use these cells with consent of the parents to derive embryonic stem cell lines and the very special things about these stem cell lines is once they are derived they can be multiplied indefinitely. We can grow them for years, we can freeze them, we can thaw them and they have the remarkable potential that they can be turned into any type of cell in our body.

This field needs a very clear and tight regulation. We certainly have such a situation in Germany. We have one of the toughest embryo protection acts in the world, which essentially prohibits any procedure which is not to the benefit of the embryo. That’s the reason why in Germany we cannot derive embryonic stem cells from fertilized oocytes, which can be done in many other countries (…)

What other possibilities does stem cell research offer that could improve people’s lives?

The prime candidates for stem cell therapies in the nervous system are diseases which lead to a loss of nerve cells or other cells in defined areas. For example, Parkinson’s disease and Huntington’s disease are diseases where we see the loss of very specific types of nerve cells in very specific areas. For replacement therapy, we know where to go and which cell type to put in (…)

from http://www.dw-world.de/dw/article/0,,4898622,00.html

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SCIENTISTS HAVE taken another important step towards producing replacement tissues for the body using stem cells. A group in Germany has developed a simpler way to produce these cells using just one special factor instead of the usual four.

The work helps build knowledge of how to produce the most powerful or “pluripotent” stem cells but new treatments using them are still some distance into the future, according to stem cell specialist Dr Stephen Sullivan.

Prof Hans Schöler led the work at the Max Planck Institute for Molecular Biomedicine and details are published this morning online by the journal Nature.

Pluripotent stem cells have huge potential to treat diseases because they are a kind of universal starter-cell, capable of becoming any of the 200 or so cells found in the body.

The best pluripotent cells are found in the developing foetus, but there are immediate ethical issues given they can only be recovered by destroying the foetus. Therefore researchers are trying to find ways to change other types of cells including adult cells into pluripotent stem cells.

Prof Schöler converted human fetal brain stem cells into pluripotent cells using just one special factor called OCT4.

Late in 2007, Prof Shinya Yamanaka and colleagues of Kyoto University announced he had used four special factors to turn human adult cells into pluripotent cells, the first to have accomplished this.

The question remains, however, whether these artificially produced stem cells will perform like natural pluripotent cells, stated Dr Sullivan, the chief scientific officer of the Irish Stem Cell Foundation, which will be formally launched towards the end of September.

from Irish Times

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Dominick Dunne

Former Hollywood producer Dominick Dunne died at the age of 83 after a long battle with bladder cancer. In past year he traveled to the Dominican Republic and Germany for stem cell treatments.

In the past year, Dunne had traveled to Germany and the Dominican Republic for experimental stem cell treatments to fight his cancer. He wrote that he and actress Farrah Fawcett were in the same clinic in Bavaria but didn’t see each other. Fawcett, a 1970s sex symbol and TV star of “Charlie’s Angels,” died in June at age 62.

In the Chicago Tribune, Liz Smith, a friend, wrote the day before Mr. Dunne’s death:

“The writer Dominick Dunne returned from a trip to Germany for stem cells, etc., but he has been in Roosevelt Hospital since getting back. He says he doesn’t feel too spry but I notice he has been receiving movie stars and VIPs in his room. He was to be moved to his apartment last Friday. We wish him all the best and are glad to report that his sons, Alex and Griffin are with him 100 percent.”

(…)

read full story on examiner.com or the new york observer

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Dr. Ewa Meyer-Blazejewska Photo: private

Journal STEM CELLS Awards Pioneering Research into Limbal Stem Cell Deficiency

A young scientist who led research into the use of stem cells from hair follicles to treat the ocular surface disease has been named the winner of the Young Investigator Award by the journal STEM CELLS.

Dr. Ewa Meyer-Blazejewska will be presented with her award at The Stem Cell Symposium, hosted by the University of Kragujevac in Serbia on October 15, 2011. The $10,000 prize is awarded annually to a young scientist whose paper has been judged to be of worldwide significance by a global jury.

Dr. Meyer-Blazejewska, from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) won the award for her research into Limbal stem cell deficiency (LSCD), a condition which causes the cornea to become cloudy and develop a rough surface causing pain and leading to blindness.

Currently, treatments focus on harvesting limbal cells from a patient’s healthy eye or from cadaveric tissue. In her pioneering research, Dr. Meyer-Blazejewska considered the potential use of stem cells harvested from hair follicles to reconstruct damaged tissue for patients who suffer from LSCD in both eyes.

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Sierra Rose Hill, a young girl from Australia with cerebral palsy who was already helped by Adult Stem Cells is off again to Germany for a 2nd stem cell treatment.  Sierra went to Germany in December, 2008 for the therapy with her own stem cells and it paid big dividends.  We first covered Sierra here in this stem cell post in March

Adult Stem Cells Successful First Time- Now Going for Two!

As a result of the first stem cell treatment, Sierra got “looser” in her limbs, more flexibility and a better ability to control her tongue. Sierra responded so well to her own Adult Stem Cells that her parents have now raised enough money to return to Germany for more stem cell therapy.

Stem Cell Research Documentary

Sierra and her parents are leaving for Germany on June 25th for the treatment. However, this time, they will have company. Pia Niebel is producing a documentary called ‘Little Mountains’ about Sierra and in Pia’s words:

‘Little Mountains’ is an intimate portrayal of an Australian family’s struggle with cerebral palsy and the risks and choices associated with emerging stem cell technologies. It is a character driven documentary that enquires about the current status of adult stem cell treatment and why it is not available in Australia.

Adult Stem Cells Available to Help In Australia? No

I often moan on how adult stem cells are not available in the United States.  However, of course, there are people everywhere who have diseases and conditions that adult stem cells could help.  There is no reason why Australia shouldn’t be making a person’s own stem cells available for treatment as well.

And as Sierra’s father said once  “If that (stem cell treatment) was available in Australia, at an affordable price, if it was at a hospital from a professional service, that could make such a huge difference to people with cerebral palsy and various other conditions,” he said. “I know they want to do their clinical trials. But they are providing this service already around the world. I would like to see it here.”

Pia is looking for funding to help her produce this Adult Stem Cell research documentary which would be a nice step in the right direction in getting Adult Stem Cell treatment approved in Australia.  If you would like to help Pia get the word out, you can contact her here:
Pia Niebel
LIGHT PUZZLE MEDIA
Creative Producer
mobile +61 (0)4 388 77 183
Email: happy@pia.net.au

Here is a preview of Pia’s stem cell research documentary featuring the lovely Sierra and her parents:

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Stem Cell Research Brings About Another Miracle

Korean doctors have apparently regrown a patient’s jawbone using the patient’s own Adult Stem Cells in yet another amazing miracle that Adult Stem Cell research has brought us.

An 18 year old Korean boy who had to have most of his jawbone and his teeth removed due to a tumor was the lucky recipient of this fantastic stem cell research victory.

The young man, who had been suffering confidence problems due to his appearance (missing his jawbone and teeth) is very happy now after the Adult Stem Cells worked their magic and regrew his jawbone so he looks normal in appearance now.

Process of Stem Cells

1. Adult Stem Cells were taken from the man’s bone marrow
2. They were then multiplied and “coached” into becoming an osteoblast- a cell responsible for bone formation
3. The new Adult Stem Cells were injected into the “damaged” area around the man’s jaw
4. 6 months-1 year the stem cells grow new bone to fill in the gap left when the jawbone and teeth were removed
5. Man’s looks better, has more confidence, happier

Stem Cell Case Study Presented at Conference

The results of the trial were published in the British medical journal BMC Medicine and it was also presented at the Korean Association of Oral and Maxillofacial Surgeons annual meeting (Those silly Maxillofacial surgeons must have forgotten my invitation)

Another Case of Adult Stem Cell Research Working Magic

This is just another instance in which the patient’s own stem cells were used to help. The patient had nothing to lose (no side effects because they were his own stem cells), and everything to gain. And gain he did with this miracle.

This reminds me of an amazing story in Germany a few years back in which they actually used a man’s back as an incubator and grew him a new jawbone

Click here to read the whole stem cell article

from Don Margolis

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