“Now that we have identified SOX10 as an initiator of myelination, we can work on developing a viral or pharmaceutical approach to inducing it in MS patients,” says Fraser J. Sim, PhD, assistant professor and senior author of the paper.
Transcription factors are proteins or molecules that bind to DNA and alter which genes are turned on, or expressed.
“If we could create a drug that would switch on SOX10, that would be therapeutically important,” Sim explains.
Removing Barriers to MS Stem Cell Therapy
Targeting SOX10 offers hope for a viable stem cell treatment for MS.
Long seen as having dramatic potential for treating
CHA Bundang Medical Center has become the first in Asia (the second in the world) to confirm that the transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells is effective in treating age-related macular degeneration (AMD) and Stargardt disease (juvenile macular degeneration) without causing dangerous side effects. Hence CHA Bundang Medical Center is now on the fast track to developing the world’s first hESC-based therapeutic product.
A Korean research team, led by Professor Song Won-Kyung from CHA Bundang Medical Center, and CHA Biotech (a leading S. Korea-based biotechnology firm focused on stem cell therapies) jointly issued an
Investigators at the Stanford University School of Medicine have devised a way to monitor neural stem cells after they’ve been transplanted into the brain.
The scientists were able to determine not only whether the stem cells transplanted into living animals survived but whether they matured into nerve cells, integrated into targeted brain circuits and, most important, were firing on cue and igniting activity in downstream nerve circuits.
Scientists at the UCSF-affiliated Gladstone Institutes and an international team of researchers have generated a human model of Huntington’s disease — directly from the skin cells of patients with the disease.
For years, scientists have studied Huntington’s disease primarily in post-mortem brain tissue or laboratory animals modified to mimic the disease. Today, in Cell Stem Cell, the international team shows how they developed a human model of Huntington’s disease, which causes a diverse range of neurological impairments. The new model should help scientists better understand the development of Huntington’s — and provide better ways to identify and screen potential therapeutics
Johns Hopkins School of Medicine (Photo credit: Wikipedia)
This year marks the 35th annual Young Investigators’ Award program, when School of Medicine trainee researchers are recognized for their stellar accomplishments in the lab. The event will take place from 4 to 6 p.m. on Friday, April 13, in Mountcastle Auditorium in the Preclinical Teaching Building on the East Baltimore campus.
Researchers will celebrate and share their findings, and 13 students and three fellows will receive awards. Each award includes a cash prize and is named for a former member of the Johns Hopkins community.
Each spring students and fellows look forward