Tag Archives: DNA

Stem cells for diabetes from cloned embryos

And now there are three: in the wake of announcements from laboratories in Oregon and California that they had created human embryos by cloning cells of living people, a lab in New York announced on Monday that it had done that and more.

In addition to cloning the cells of a woman with diabetes, producing embryos and stem cells that are her perfect genetic matches, scientists got the stem cells to differentiate into cells able to secrete insulin.

That raised hopes for realizing a long-held dream of stem cell research, namely, creating patient-specific replacement cells for people with diabetes, Parkinson’s disease,
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Protecting the future: how plant stem cells guard against genetic damage

Scientists at the John Innes Centre in Norwich, UK, have shown how plants can protect themselves against genetic damage caused by environmental stresses. The growing tips of plant roots and shoots have an in-built mechanism that, if it detects damage to the DNA, causes the cell to ‘commit suicide’ rather than pass on its defective DNA.

Plants have, at the very tips of their roots and shoots, small populations of stem cells, through which they are able to grow and produce new tissue throughout the plant’s life. These stem cells are the precursors to producing plant tissues and
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The Role of Hiwi in Stem Cell Maintenance and Sarcomagenesis

Sarcomas are cancers of connective tissues, such as bone, adipose and cartilage, and are thought to arise from the aberrant development of the mesenchyme. As such, mesenchymal stem cells are thought to be the cell of origin for sarcomas. Genetic or epigenetic lesions at particular points during the differentiation of a mesenchymal stem cell into its terminal mesenchymal cell type are able to give rise to specific subtypes of sarcomas.

Recently, a number of reports have identified elevated expression of the human Piwi homolog–called Hiwi–in a variety of human cancers, including gastric cancer, pancreatic cancer, gliomas and, most relevant for
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