Monash University researchers are shedding light on the complex processes that underpin the creation and differentiation of stem cells, bringing closer the promise of ‘miracle’ therapies.
Dr Jose Polo of the Australian Regenerative Medicine Institute (ARMI) and the Department of Anatomy and Developmental Biology and his team, with collaborators at Harvard, have comprehensively mapped, for the first time, the process by which mature cells are re-programmed to become an induced pluripotent stem (iPS) cell.
iPS cells behave almost exactly like embryonic stem cells – they can become any cell in the body – but come without the ethical and scientific pitfalls.
Scientists and transplant clinicians at the Ansary Stem Cell Institute at Weill Cornell Medical College and the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center have been awarded a $15.7 million, four-year research grant from the New York State Stem Cell Science Program (NYSTEM).
The scientists will translate their approach to manipulate hematopoietic stem cells to cure acquired and inherited blood disorders. For many patients with such blood diseases, including sickle cell disease, the only hope for a cure requires transplanting normal blood stem cells.
But in many instances suitable blood stem cells cannot be found or there are
Each one of us receives approximately 60 new mutations in our genome from our parents.
This striking value is reported in the first-ever direct measure of new mutations coming from mother and father in whole human genomes published today.
For the first time, researchers have been able to answer the questions: how many new mutations does a child have and did most of them come from mum or dad? The researchers measured directly the numbers of mutations in two families, using whole genome sequences from the 1000 Genomes Project. The results also reveal that human genomes, like all genomes, are changed
Pier Paolo Parnigotto with Mariateresa Conconi
After a trachea transplant that was not rejected, performed in Barcelona by Italian surgeon Paolo Macchiarini, soon other organs and biotech tissues will be reconstructed in the lab thanks to a technique developed by the University of Padova. Bones, livers, the esophagus, pancreases, and muscles will be next, in research that will possibly take place in the Veneto. According to Pierpaolo Parnigotto, 61 year old professor of anatomy, who together with Maria Teresa Conconi carried out tissue engineering research for 15 years in the development of biotech organ grafts that
The prospect of treating genetic diseases with corrected stem cells grown from patients’ own bodies has moved closer, after the results of a remarkable experiment.
Scientists have successfully reprogrammed skin tissue from people with a rare form of anaemia to create powerful stem cells, while at the same time rectifying the genetic defect that causes the condition.
The corrected stem cells could be grown into blood precursor cells for therapy. As these would carry a patient’s own DNA, except for the mutation responsible for the illness, they could be transplanted without risk of rejection by the body’s immune system.
Though the research