Tag Archives: DNA repair

Stem cells and you can forget diabetes

A team of researchers has brought the end of diabetes closer to reality by announcing a new breakthrough that could lead directly to a cure and not just a treatment for the disease.

The scientists discovered a protein that activates the maturation process in vitro, overcoming this longstanding obstacle in diabetes therapy development.

“In a dish, with this one switch, it’s possible to produce a functional human beta cell that’s responding almost as well as the natural thing,” says senior author Ronald Evans of the Salk Institute. “This has been a major blockade, and overcoming it has been a major challenge
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Stem Cells versus Progeria

Children with progeria, a rare disorder that causes premature aging, die in their teens of ailments that are common in octogenarians: heart failure and stroke. Kan Cao, a University of Maryland assistant professor of cell biology and molecular genetics, urgently wants to help find a cure. Cao and her colleagues have taken a big step in that direction, showing that a toxic protein destroys muscle cells inside the patients’ arteries. The researchers suspect the damaged arteries are more prone to failure.

The researchers conducted their experiments on smooth muscle cells that they genetically engineered. “This gives us a very good
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Genetic abnormalities associated with the creation of stem cells

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Discovery sheds new light on the process of stem cell generation, and will help promote safer stem-cell based studies and future clinical trials.

Dr. Andras Nagy’s laboratory at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Dr. Timo Otonkoski’s laboratory at Biomedicum Stem Cell Center (University of Helsinki), as well as collaborators in Europe and Canada have identified genetic abnormalities associated with reprogramming adult cells to induced pluripotent stem (iPS) cells. The findings give researchers new insights into the reprogramming process, and will help make future applications of stem cell creation and subsequent use safer.
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Patients’ own stem cells may protect against toxins of chemotherapy

Chemotherapy saves lives, but it also kills healthy tissue like bone marrow. According to a new study involving three patients with glioblastoma, a deadly cancer of the brain, stem cells from cancer patients’ own blood may protect their bone marrow from the toxic effects of treatment.

Glioblastomas often carry an active form of a gene called MGMT, which is a DNA repair enzyme that protects the cancer cells against chemotherapy. To overcome that protective effect, doctors use benzylguanine, a drug that blocks MGMT – but that drug also makes bone marrow and blood cells vulnerable. For this study, scientists at Fred Hutchinson
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Fish oil may help cure leukemia

A compound found in fish oil, which apparently kills leukaemia stem cells, may lead to the cure of the disease, a new study including Indian origin researcher has revealed.

The compound, delta-12-protaglandin J3, or D12-PGJ3 targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, according to Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences.

He said that the compound is produced from EPA, Eicosapentaenoic Acid, an Omega-3 fatty acid found in fish and in fish oil.

“Research in the past on fatty acids has shown the health benefits
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