In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
In both mice and a Phase 1 human clinical trial, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for
A group of British doctors are preparing for human clinical trials that will take a person’s bone marrow stem cells, transform them into heart stem cells and inject them into the heart, where they can go to work repairing damage.
“Placing heart stem cells into the heart to repair has a very good chance of working; because the stem cells are the patient’s own there are no problems with rejection,” said Professor Sian Harding, of Imperial College London.
The British researchers plan to use a technique that was pioneered at the Mayo Clinic. They will remove 40 milliliters of bone marrow
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Scientists at the Ottawa Health Research Institute have been awarded $2.4 million to develop stem-cell therapies that could reverse blindness.
The five-year grant is to help researchers develop better methods for turning stem cells, harvested from human embryos and from patients themselves, into different kinds of eye cells.
If successful, this form of stem-cell therapy would take medicine one more step toward rebuilding the body’s sick and damaged parts.
The treatment could benefit more than one million Canadians affected by degenerative eye diseases.
Christopher J. Centeno, M.D.
A leading adult stem cell therapy organization is warning the public that the Food and Drug Administration (FDA) has teamed up with the pharmaceutical industry to declare a person’s own stem cells to be a “drug” which can be regulated, thus slowing down the progress of these promising therapies by requiring years of clinical trials before use.
Dr. Christopher Centeno, of Regenerative Science, Inc. of Broomfield, Colo., realized what was happening when he was contacted by the FDA last summer about his work using a patient’s own stem cells to regenerate bone and cartilage.
The past few years brought high development in obtaining and culturing autologous adult stem cells. In this paper we review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells (MSCs) can be obtained from bone marrow but it is associated with a painful biopsy procedure.
Collection of muscle-derived stem cells (MDSCs) is less harmful because the skeletal muscle biopsy is performed with a small caliber needle in local anesthesia. The stem-based therapy could be the next